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《Modern Preventive Medicine》 2007-05
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RANDOMIZED CONTROLLED TRIAL OF EDARAVONE INJECTION IN THE TREATMENT OF ACUTE CEREBRAL INFARCTION

ZHOU Mu-ke,Yang Jie,HE Li,et al.(Department of Neurology,HuaXi Hospital,Sichuan University,Chengdu 610041,China)  
[Objective]To evaluate the efficacy and safety of Edaravone injection in the treatment of acute cerebral infarction in the vascular distribution of the internal carotid artery within 48 hours from the onset.[Methods]Patients consistent with the inclusion criteria were asked to participate in the trial.They were randomized in a double-blind manner to receive intravenously either Edaravone injection 30 mg twice per day(study group;22 cases)or placebo 30 mg twice per day(control group;22 cases).Patients in each group were given Venoruton injection 200 mg once per day intravenously and Aspirin 100 mg once per day orally.The duration of treatment was 14 days for both groups.The European Stroke Scale(ESS)and Barthel Index(BI)were used to evaluate the recovery of neurological functions.[Results]ESS and BI scores increased significantly in study group compared with that of control group after treatment.No serious adverse drug reaction were found in these two groups.[Conclusion]Edaravone injection is effective and relatively safe in the treatment of acute cerebral infarction in the vascular distribution of the internal carotid artery.
【Key Words】: Edaravone injection Cerebral infarction RCT
【CateGory Index】: R743.3
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【Co-references】
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1 Wang Yuhui, Shao Fuyuan, Xia Chunlin, et al. Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China;Caspase-3 expression on MCA ischemia-reperfusion in rat models[J];Journal of Clinical Neurology;2003-04
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【Secondary References】
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1 JIA Chun-hong,ZHANG Hong(Department of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China);Effect of edaravone on acute cerebral infarction[J];Practical Pharmacy and Clinical Remedies;2009-01
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