Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Modern Preventive Medicine》 2007-11
Add to Favorite Get Latest Update

A META-ANALYSIS OF LEFLUNOMIDE IN THE TREATMENT OF RHEUMATOID ARTHRITIS

ZHU Xiang-zhu,ZHOU Xing-jun,LU Ai-qin,et al.(School of Public Health,Nantong University,Nantong 226001,China)  
[Objective]To evaluate the efficacy and safety of Leflunomide(LEF)in the treatment of Rheumatoid Arthritis(RA).[Methods]The literature about the effect of LEF on patients with RA from January,1989 to December,2005 were searched for according to inclusion and exclusion criteria. Nine studies were chosen at last for Meta-analysis. The data were analysed by REVMAN4.2 software.[Results]12 weeks after therapy,no significant difference in the response rate was found between LEF and controll group(RR=1.05,95%CI=0.98-1.13). The incidence of adverse response for LEF was lower than MTX(RR=0.53,95%CI=0.38-0.72). [Conclusion]LEF is effective in the treatment of RA and it is with less adverse respose than MTX. Its efficacy is similar to MTX,but the incidence rate of adverse response and the rate of withdrawal were lower than that in MTX group.
【Fund】: 南通市科技计划项目(S40013)
【CateGory Index】: R593.22
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved