THE RELATIONSHIP BETWEEN TYPE 2 DIABETIC MACROANGIOPATHY AND THE LEVELS OF SERUM MATRIX METALLOPROTEINASE 2 AND TISSUE INHIBITOR OF METALLOPROTEINASE 2
PAN You-jin,ZHAO Xiang-tong,WU Chao-ming,et al.(Department of Endocrinology,The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China)
[Objective]To investigate the association between the levels of serum matrix metalloproteinase 2(MMP-2)and tissue inhibitor of metalloproteinase 2(TIMP-2)and type 2 diabetic macroangiopathy.[Methods]The serum MMP-2 and TIMP-2 were determined by ELISA in 30 healthy controls and 57 type 2 diabetes patients(including 27 type 2 diabetes without complications and 30 type 2 diabetic macroangiopathy).[Results]The serum MMP-2 of type 2 diabetic macroangiopathy patients was obvious higher than that of single type 2 diabetes patients and the controls(P﹤0.01).And it had positive correlation with the levels of FBP、HbA1c、TG、TC、SBP and DB.While the level of TIMP-2 was on the contrary.[Conclusions]Detection of MMP-2 and TIMP-2 may play an important role in surveillance of the development and progression of type 2 diabetic macroangiopathy.