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《Modern Preventive Medicine》 2010-09
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EFFECTS OF ZINC DEFICIENCY ON THE EXPRESSION OF UCH-L1 IN THE HIPPOCAMPUS OF RATS

LU Ying, ZHAO Jian-ya, QIU Liang-lin, et al. (Public Health School, Nantong University, Nantong 226007, China)  
[Objective] To explore the effects of zinc deficiency on the expression of UCH-L1 in hippocampus of rats. [Methods] SD rats were randomly divided into zinc normal group (ZN), pair-fed group (PF) and zinc deficient group (ZD). ZN group were fed with zinc- normal diet (32.5mg / kg), PF group were fed with zinc-high diet (73.5 mg / kg), while ZD group were fed with zinc-deficient diet (1.2 mg / kg). The rats were sacrificed after 4 weeks and the tissue samples of hippocampus were taken immediately. The expression of UCH-L1 mRNA was detected by RT-PCR, and the expression of UCH-L1 protein was detected by Western blot. [Results ] Compared with ZN group and PF group, the expression of UCH-L1 mRNA and protein in ZD group were both down-regulated significantly. [Conclusion] The abnormal change of expressions of UCH-L1 is observed in the hippocampus of zinc deficiency rats.This might be one of the possible mechanisms of cognitive impairment induced by zinc deficiency.
【CateGory Index】: R151
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 SUN Jin-Hua,CHENG Han-Hua,ZHOU Rong-Jia(Department of Genetics and Center for Developmental Biology,College of Life Sciences,Wuhan University,Wuhan 430072,China);Ubiquitin C-terminal Hydrolases L1:Physiological and Pathological Significance[J];生物化学与生物物理进展;2007-08
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 TANG Shijun;CHEN Song;YE Mao;Molecular Science and Biomedicine Lab,College of Biological Sciences,Hunan University;College of Life Science,Hunan Normal University;;Deubiquitinases and Tumor[J];激光生物学报;2014-04
2 GU Yan-qiong;SHI Yan;WANG Jian;SUN Zhao-gui;Key Laboratory of Contraceptive Drugs & Devices of NPFPC,Shanghai Institute of Planned Parenthood Research;;Effects and Preliminary Mechanisms for Diethylstilbestrol on Follicular Development in Prepubertal Mice and Rats[J];实验动物与比较医学;2013-02
3 LU Ying, ZHAO Jian-ya, QIU Liang-lin, et al. (Public Health School, Nantong University, Nantong 226007, China);EFFECTS OF ZINC DEFICIENCY ON THE EXPRESSION OF UCH-L1 IN THE HIPPOCAMPUS OF RATS[J];现代预防医学;2010-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 SUN Zhao Gui KONG Wei Hua YAN Shan GU Zheng TSO Jia Ke (National Laboratory of Contraceptives and Devices Research , Shanghai Institute of Planned Parenthood Research , Shanghai 200032, China; College of Life Science, Shandong University, Ji'nan 250100, China; Shandong University of Traditional Chinese Medicine, Ji'nan 250014, China);THE FUNCTIONS IN THE PROGESTERONE-INDUCED OOCYTE MATURATION OF TOAD UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (tUCH) IS INDEPENDENT OF ITS UCH ACTIVITY[J];实验生物学报;2003-02
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