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《Modern Hospital》 2013-06
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PTERYGIUM TREATED WITH EXTENSIVE EXCISION COMBINED WITH AMNIOTIC MEMBRANE GRAFT AND USE OF MITOMYCIN C

GONG Hua,ZHU Shiping,GONG Xiangming The Liwan Hospital of Guangzhou Medical College,Guangzhou City,Guangdong Province 510170 PRC  
Objective To evaluate the effect and safety of extensive pterygium excision combined with amniotic membrane transplantation and/or use of mitomycin C in treating pterygium. Methods A retrospective study was done in 297 eyes of 259 patients with pterygium.227 eyes in 193 cases suffered with primary pterygium,and 70 eyes in 66 cases suffered with recurrent pterygium.According to operative style,the treated cases were divided into 6 groups.Group A(simple extensive excision of primary pterygium) 35 cases(42 eyes);Group B(primary pterygium excision combined with intraoperative mitomycin,MMC) 26 cases(30 eyes);Group C(primary pterygium excision combined with amniotic membrane transplantation,AMT) 90 cases(105 eyes);Group D(primary pterygium excision combined with AMT plus MMC) 42cases(50 eyes);Group E(recurrent pterygium excision combined with AMT) 40 cases(43 eyes);Group F(recurrent pterygium excision combined with AMT and MMC) 26 cases(27 eyes).The follow up periods were 1 year to 8 years. Results The respective recurrence rate in group A through F was 23.8%,10.0%,6.7%,4.0%,13.9% and 11.1%.Between Group A and group C,Group A and group D,differences were significant obvious(p0.01).The recurrence rate between any other groups was no significant difference(p0.05).No severe complications were encountered in every group. Conclusion Pterygium extensive excision combined with AMT and intraoperative 0.02% MMC for 5 minute or excision combined with AMT alone can reduce the recurrent rate after primary pterygium and recurrent pterygium surgery.Primary pterygium simple excision plus intraoperative MMC is effective too.Pterygium extensive excision plus intraoperative MMC and/or AMT were safer and effective.
【Fund】: 广州市荔湾区科技计划项目(编号:20121214203)
【CateGory Index】: R779.6
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