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《Modern Diagnosis & Treatment》 2010-03
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Efficacy Observatiom on PAS Therapy for Carotid Atherosclerosis

LI Ying,ZHU Yu-hong(Department of Neurology,the Second Affiliated Hospital of Kunming Medical College,Kunming 650000,China)  
Objective To investigate the effects of combination therapy of probucol,atorvastatin calcium and aspirin drugs(PAS) on patients with carotid atherosclerosis.Method A total of 80 patients with ischemic cerebrvascular disease complicated with carotid arteriosclerosis were randomized into two groups.40 cases in PAS treatment group were treated with probucol(0.5g/d),atorvastatin calcium(20mg/d) and aspirin(100mg/d).40 cases in AS control group were treated with atorvastatin calcium(20mg/d) and aspirin(100mg/d).The serum lipids(TC,TG,LDL-C,HDL-C),high-sensitivity C-reactive protein(hs-CRP),intima-media thickness(IMT) of carotid arterial and carotid plaques score were measured before and three months after treatment.Results Serum total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),hs-CRP levels in both PAS treatment group and AS control group reduced after the treatment(P0.05),especially in PAS group(P0.01).Carotid plaques scrore in PAS group was on a slight downward trend(P0.05).Conclusions(1)The effects of combination therapy of probucol,atorvastatin and aspirin drugs of adjusting lipids and decreasing the level of inflammatory factor hs-CRP are better than that of combination therapy of probucol and atorvastatin.(2)Long-term further observation is demanded to draw a conclusion on the stability of carotid plaque.
【CateGory Index】: R543
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