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《Modern Diagnosis and Treatment》 2015-16
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The Effects of Blood Glucose on CD4~+CD25~+ Regulatory T Cells in Patients with Latent Autoimmune Diabetes in Adults

DENG Li-juan;WU Yong-xin;LIN Lin;WANG Hong-mei;ZHA Zhi-qiong;Meizhou People's Hospital;  
Objective To investigate the effects of different blood glucose levels on CD4+CD25+regulatory T cells and IL-10 in patients with latent autoimmune diabetes in adults(LADA).Methods There were 104 cases of LADA within five years of LADA, they were divided to intensive therapy group(group A and B)and non- intensive therapy group(group C and D) according to their choice. Before treatment and after two weeks and four weeks, fasting blood glucose(FBG), glycosylated hemoglobin(Hb A1C) and islet cell function(fasting C-peptide)were detected respectively. Determine the lymphocytes subpopulations(CD4+CD25+T cell) in peripheral blood mononuclear cells by flow cytometry. Levels of IL-10 peripheral blood were assessed by ELISA.Results The function of islet was progressed in group A and the rate of CD4+CD25+regulatory T cells and the levels of IL-10 were increased by the 2-weeks insulin intensive therapy on group A and B but group C or D. As the experiment proceeds to four weeks, patients with islet cell function continuously improved, CD4+CD25+regulatory T cells and the levels of IL-10 increased progressively. Conclusions Patients with LADA treated by insulin intensive may make the blood glucose standardization and ameliorate the immunodeficiency by increasing the rate of CD4+CD25+T cell and and the levels of IL-10,and then improve the function of islet.
【CateGory Index】: R587.1
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