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《Journal of Cardiovascular and Pulmonary Diseases》 2002-04
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Effects of Tetrandrine on early after depolarizations and arrhythmias induced by Cesium Chloride in rabbits

JIANG Juquan, ZENG Qiutang, CAO Linsheng, et al.Union Hospital of Tongji Collage,Huazhong Science and Technology University Wuhan\ 430022  
Objectives:We studied the effects of tetrandrine on early afterdepolarizations(EAD)and arrhythmias induced by Cesium Chloride in rabbits.Method:14 rabbits were randomly divided into two groups\|tetrandrine group and control group.Each group included 7 rabbits.Tetrandrine was intravenously given(0.5 mg/kg/min)in ten minutes in tetrandrine group,while normal saline was given in control group.Then,Intravenous bolus doses of Cesium Chloride(1.5 mmol/kg)were given to above two groups.We recorded the lead Ⅱ electrocardiogram (ECG)and the endocardial monophasic action potential(MAP)of the right ventricle before and after administration of Cesium Chloride.Result:Cesium Chloride was effective to induce the EAD,decrease the MAP amplitude(MAPA),prolong the monophasic action potential duration at 90% repolarization(MAPD 90) and R\|R interval in two groups.But the EAD amplitude was lower in tetrandrine group than in control group.The rate of incidence of ventricular arrhythmias was lower in tetrandrine group than in control group.Conclusion:Tetrandrine is effective to resist the EAD induced by Cesium Chloride and inhibit ventricular arrlythmias.The mechanism may be Ca~ ++channel was blocked by tetrandrine and slows the inward current was slowed.
【CateGory Index】: R285.5
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