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《Journal of Cardiovascular and Pulmonary Diseases》 2009-03
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The Effects of different diuretics on the electrolytes in cardiac valve replacement surgery with cardiopulmonary bypass

JIA Zaishen, HOU Xiaotong, LIU Xiaoming, LIU Xiaojun, LI Yanping, SUN Zhiquan, HAN Jingmei, GONG Qingcheng Department of Cardiopulmonary Bypass, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China  
Objective:To observe the effect of torasemide and furosemide on the change of electrolytes in cardiac valve replacement surgery.Method:Sixty patients undergoing elective cardiac valve replacement surgery with cardiopulmonary bypass(CPB)were randomly assigned into two groups, torasemide group(group A)30 cases and furosemide group(group B)30 cases. Blood samples were taken to detect blood concentration of K~+、Na~+、Mg~ ++ 、Ca~ ++ at five time points: after induction of anaesthesia, 15 min after aortic cross-clamping, 15 min after declamping, after ending CPB, and 2 hours postoperatively; Spontaneous resuscitation rate and volume of urine during CPB were recorded.Result:Blood concentration K~+ of group A was significantly higher than group B (P0.01)at 15 min after declamping ; There were no significant differences of blood concentration Na~+、Mg~ ++ 、Ca~ ++ with respect to induction of anaesthesia, 15 min after aortic cross-clamping, 15 min after declamping, after ending CPB, and 2 hours postoperatively between two groups(P0.05). Conclusion:Torasemide can be used as diuretic in cardiac valve replacement surgery, but attention must be paid to avoid the high blood concentration of K~+ after declamping.
【CateGory Index】: R654.2
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