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Effect of Gypenosides on hemodynamics and nitric oxide in rabbits injected with endotoxin

TANG Chao ke, HU Bi,LIAO Duan fang Department of Diagnostics, Hengyang Medical College, Henyang Hunan 421001,China  
AIM:To investigate the effects of Gypenosides(GPS) on hemodynamics and nitric oxide levels in rabbits injected with endotoxin. METHODS:Rabbits were randomly divided into three groups: control, endotoxin (LPS), and LPS plus GPS. The animals were anaethetized with intravenous injection of 20% ethyl urethane. Nitric oxide levels were determined by colorimetric analysis.The parameters of hemodynamics, including mean arterial pressure (MAP), heart rate (HR), peak value of ventricle pressure (PEAK), ±d p /d t max , area of cardiac force circle (AREA), peaktime (PT), left ventricle end diastolic pressure (LVEDP) and time duration of ascendent and descendent slope (±T), were measured by SMUP A, a bioinformatic processor. RESULTS:All the investigated values in the control group were not significantly changed during the experiment. Compared with those of the LPS group, the values of HR, PEAK, ±d p /d t max and AREA, PT, LVEDP and ±T changed less in GPS group at 4 h and 6 h after the administration of GPS. The plasma level of nitric oxide in the GPS group was lower than that in the LPS group but higher than that in the control group after the administration of GPS. MAP showed significant difference between the LPS and GPS groups, and both of them were lower than that of the control group. The investigation demonstrated that Gepenosides prominently improved the hemodynamics of the rabbits, and delayed the animal death caused by endotoxin. CONCLUSON: GPS might protecte endotoxin induced impairment of hemodynamics in rabbits, that initiation and development of endotoxin induced shock might be retarded by administration of GPS,and that the mechanism of the improvement might involve the decrease of NO level and the improvement of hemodynamics.
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