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Clinical study of changes in plasma endothelin and tumor necrosis factor levels in patients with coronary heart disease

LIANG Wei jun,FU Yi bing,CHEN Jian ying(Department of Cardiology,Affiliated Hospital of Guangdong Medical College,Zhanjiang,Guangdong 524001,China)  
AIM:To study the clinical significance of changes in plasma endothelin(ET) and tumor necrosis factor(TNF) levels in patients with coronary heart disease(CHD). METHODS:Tests of ET and TNF in blood plasma were performed in 67 patients with CHD. 28 healthy subjects served as mormal controls. RESULTS:plasma ET and TNF levels in the patients were much higher than those in the normal subjects(all P 0.01). Plasma ET and TNF increased with the progressive severity of CHD. CONCLUSION:ET and TNF are associated with CHD.
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