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《Chinese Heart Journal》 2007-02
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Sympathetic neural remodeling after myocardial infarction correlates with growth associated protein-43 in rabbits

ZHANG Chao,ZHENG Qiang-sun,GAO Yuan,LEI Jing-yi,LIU Wen-xiu,ZHANG Zhong,ZHANG Xian-wei(Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi′an 710038,Shaanxi,China)  
AIM To explore the expression of growth associated protein-43(GAP-43) and its effect on neural remodeling after myocardial infarction(MI) in rabbits and the effect of β-blocker on neural remodeling.METHODS Samples were obtained from the MI rabbits in peri-infarcted area,ventricular septum and right ventricle(RV).By immunohistochemistric method and computer image processing technique,the expression of GAP-43 and the density and extent of sympathetic innervation were examined in different groups(3 days,7 days,30 days after MI and propranolol taken orally).RESULTS In 3 day group,the expressions of GAP-43 were significantly higher in peri-infarcted area and higher in RV and ventricular septum than those in control areas(P0.01),the density of sympathetic nerve decreased in peri-infarcted area and ventricular septum(P0.01) and increased in RV significantly(P0.01),and GAP-43 expression correlated with sympathetic innervation in RV(P0.05).In 7 day group,the expressions of GAP-43 and density of sympathetic nerves in peri-infarcted area,ventricular septum and RV significantly increased(P0.01),and GAP-43 expression correlated with sympathetic innervation in peri-infarcted area(P0.01).In 30 day group,the expressions of GAP-43 decreased significantly in peri-infarcted area,ventricular septum and RV(P0.01),and the density and the extent of sympathetic nerve were higher than those in 3 and 7 day groups.Propranolol decreased the density of sympathetic innervation in ventricular septum and RV(P0.05) and normalized the extent of sympathetic innervation in the whole ventricle after left ventricular MI.CONCLUSION The expression of GAP-43 in myocardium is dynamic and correlated with the density and extent of sympathetic innervation.β-blocker plays an important role in improving this sympathetic neural remodeling.
【Fund】: 国家自然科学基金项目资助(No.39700165)
【CateGory Index】: R542.22
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