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《Chinese Heart Journal》 2007-02
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Sympathetic neural remodeling after myocardial infarction correlates with growth associated protein-43 in rabbits

ZHANG Chao,ZHENG Qiang-sun,GAO Yuan,LEI Jing-yi,LIU Wen-xiu,ZHANG Zhong,ZHANG Xian-wei(Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi′an 710038,Shaanxi,China)  
AIM To explore the expression of growth associated protein-43(GAP-43) and its effect on neural remodeling after myocardial infarction(MI) in rabbits and the effect of β-blocker on neural remodeling.METHODS Samples were obtained from the MI rabbits in peri-infarcted area,ventricular septum and right ventricle(RV).By immunohistochemistric method and computer image processing technique,the expression of GAP-43 and the density and extent of sympathetic innervation were examined in different groups(3 days,7 days,30 days after MI and propranolol taken orally).RESULTS In 3 day group,the expressions of GAP-43 were significantly higher in peri-infarcted area and higher in RV and ventricular septum than those in control areas(P0.01),the density of sympathetic nerve decreased in peri-infarcted area and ventricular septum(P0.01) and increased in RV significantly(P0.01),and GAP-43 expression correlated with sympathetic innervation in RV(P0.05).In 7 day group,the expressions of GAP-43 and density of sympathetic nerves in peri-infarcted area,ventricular septum and RV significantly increased(P0.01),and GAP-43 expression correlated with sympathetic innervation in peri-infarcted area(P0.01).In 30 day group,the expressions of GAP-43 decreased significantly in peri-infarcted area,ventricular septum and RV(P0.01),and the density and the extent of sympathetic nerve were higher than those in 3 and 7 day groups.Propranolol decreased the density of sympathetic innervation in ventricular septum and RV(P0.05) and normalized the extent of sympathetic innervation in the whole ventricle after left ventricular MI.CONCLUSION The expression of GAP-43 in myocardium is dynamic and correlated with the density and extent of sympathetic innervation.β-blocker plays an important role in improving this sympathetic neural remodeling.
【Fund】: 国家自然科学基金项目资助(No.39700165)
【CateGory Index】: R542.22
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Qin Dengyou;Wang Guoying;Liu Dayong;Hu Yaoming;Zhong Shizhen(Department of Anatomy,Bengbu Medical College,Anhui 233003);Immunohistochemistry for GAP-43 expression and AChE staining of injured nerve and nerve regeneration[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-02
2 FAN Shao di, XU Jian zhong, LI Qi hong, WU Kang (Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038);Expression of GAP-43 mRNA in course of injury and repair of peripheral nerve during and after limb lengthening in rabbits[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-02
3 Meng Fandong; Ju Gong(Institute of Neurosciences, Fourth Military Medical University, Xi'an 710033);Distribution of GAP-43 in the anterior pituitary of rat[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1997-06
4 Zhu Cuiqing,\ Tang Chongren,\ Lu Shiduo,\ Dong Hongxing (Shanghai Medical University, State Key Laboratory of Medical Neurobiology Shanghai 200032 China) \;;THE EFFECT OF ACUPUNCTURE ON EXPRESSION OF GAP43 IN DORSAL ROOT GANGLION NEURONS AND DORSAL HORN OF SPINAL CORD——AN OBSERVATION ON RAT WITH PARTIAL DORSAL ROOT RHIZOTOMY[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1999-03
5 PAN Hua-ping1,2,FENG Hui2(1The Second Clinic Medicine of Nanjing Uiniversty of TCM,Nanjing 210046,China;2Nanjing Jiangbei People's Hospital of Southeast University,Nanjing 210048,China);Effect of acupuncture and rehabilitation therapy on nerve growth related proteins in patients with brain injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-03
6 Chang Lan(Department of Veterinary medicine, Agriculture and Animal Husbandry College of Qinghai University, Xining 810003);Distribution and Developmental Changes of the Growth Associated Protein in the Central Nervous System[J];;1999-02
7 FU Shuang-lin,ZHANG Jian-tao,ZHAO Jing-wei,et al(Department of Neurosurgery,First Hospital of Jilin University,Changchun 130021,China);Expression of Growth-associated Protein-43 in Central Nervous System of Rats with Traumatic Brain Injury[J];Chinese Journal of Biologicals;2009-07
8 FENG Jun-ji1,LIU Zhong-hu1,YU Shi-yuan2,XIANG Xi-xi1,YUE Xiao-hui1,TONG Chuan1 (1.College of Animal Husbandry and Veterinary,Henan Agriculture University,Zhengzhou 450002,Henan,China;2.College of Life Science,Northwest Normal University,Lanzhou 730070,Gansu,China);Cloning and bioinformatics analysis of growth associated protein(GAP-43) encoding region of Bufo gargarizans[J];Journal of Northwest Normal University(Natural Science);2009-04
9 Zhang Shou and Chang Lan (Agriculture and Animal Husbandry College of Qinghai Univ,Xining 810003) Fan Guangli (Northwestern Agric Univ,Yangling);Distribution and Developmental Changes of Growth Association Protein 43(GAP 43): Immunoreactive Fibers in the Cerebellum of Late Embryo and Early Chick[J];Animal Husbandry & Veterinary Medicine;1999-S1
10 RUI Yong-jun ZHANG Lei WANG Jun Wuxi Hand Surgery Hospital,Jiangsu 214061,China;Effects of ultra short wave on GAP-43 and CGRP expression in the spinal cord after sciatic nerve lesions in rats[J];Chinese Journal of Hand Surgery;2006-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHU Xiao rong, HUANG Yu fen, LONG Ming zhi (The Second Affiliated Hospital of Nanjing Medical University, Jiangsu Nanjing 10011,China);The study of ventricular arrhythmia and QT dispersion in patients with diabetes mellitus[J];Hebei Medicine;2000-12
2 HU He-Sheng, YAN Su-Hua, WANG Qing, CHEN Wen-Juan, LI Xiao-Lu, XUE Mei, and SUN Xue-Lin (Department of Cardiology, Qianfoshan Hospital of Shandong Province, Jinan 250014, China);Effects of Metoprolol Treatment on Neural Remodeling After Myocardial Infarction in Rabbits[J];Chinese Journal of Arteriosclerosis;2007-03
3 ZHENG Song-Ling1,YAN Su-Hua2,SONG Zhong-Ju1,HU He-Sheng2,CHENG Wen-Juan2,XUE Mei2,and ZHANG Jun-Yi1(1.School of Medicine,Shandong University,Jinan 250012,China; 2.Department of Cardiology,Qianfoshan Hospital of Shandong Province,Jinan 250014,China);Changes of Autonomic Nerves and Its Effects on Inducible Ventricular Arrhythmias in Diabetic Rabbits After Myocardial Infarction[J];Chinese Journal of Arteriosclerosis;2009-02
4 Dai Jia, Wu Han, Shen Hua, et al. Shanghai First People’s Hospital, Shanghai 200080;The assessment of HRV in the aged patients with diabetes[J];PRACTICAL GERIATRICS;2000-01
5 XUE Hong-jie, ZHAO Ling-hui, XU Jia-hui, NI Xiu-qin. The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China;Changes of cholinergic nerve morphosis and density in the left ventricle of rats after acute ischemic injury induced by myocardial infarction[J];Chinese Journal of Endemiology;2006-02
6 GAO Ping,JIA Ruhan,WANG Xueyu. Department of Nephrology,Renmin Hospital, Wuhan University, Wuhan 430060, China;Effect of irbesartan on activation of renal nuclear factor-kappa B in experimental type 2 diabetic rat[J];Chinese Journal of Nephrology;2002-05
7 ZHAO Xiaohua *,YANG Yan,SONG Zheng,LI Xing,LI Li,ZHANG Xizhong. * Second Hospital of Shanxi Medical University, Taiyuan 030001,China;Effect of superior fiber complex on insulin sensitivity index and blood lipids in non-insulin dependent diabetes mellitus rats[J];Chinese Journal of Preventive Medicine;2002-03
8 LI Jing-jie, QU Xiu-fen, YUE Le, XI Yang, GU Hong-yue, WANG Gui-zhao, HUANG Yong-lin. Department of Cardiology, First a ffiliated Hospital of Harbin Medical University, Harbin 150001, China;Regional denervation after myocardial infarction and its effect on ventricular r epolarization[J];National Medical Journal of China;2006-02
9 XUE Hong-jie , ZHAO Ling-hui ,XU Jia-hui,et al. The First Affiliated Hospital of Harbin Medical University, Harbin 150001,China;The experimental study on reinnervation of acetylcholinesterase positive nerves after acute myocardial infarction[J];Chinese Journal of Clinical Anatomy;2006-05
10 ZHANG Qiu_ju, YUAN Zhong_hua,Kazuhiko Tsutsumic 2,XIE Yu_xiang 1, WANG Zong_bao 3,FU Guo_xiang 1,LONG Guang 1, YIN Wei_dong 4 Department of Biochemistry and Molecular Biology, Nanhua University Medical College, Hengyang;NO-1886 improves glucose metabolism in high fat/ high sucrose-fed New Zealand white rabbits[J];China Journal of Modern Medicine;2003-22
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