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《ZHEJIANG CANCER JOURNAL》 1999-03
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Preliminary Report of Malariotherapy for Advanced Tumors

Chen Xiaoping; Hemp J. Heimlich; Xiao Binquan; et al.(The Municipal Health and Anti-Eqidemic Station of Guangzhou, Guangzhou 510080; The Heimlich Institute, Cincinnati, USA )  
[Purpose]To explore the indications and effectiveness of malariotherapy(MT) for cancer, relation between courses of the therapy andeffectiveness, affection of other anticancer therapies on MT and to observe side-effects and complications of the therapy through preliminary clinicaltrials. [Methods]Seven patients with advanced cancers were selected for the clinical trials. They respectively suffered from adenocarcinoma of breastwith metastases of bones; small cell undifferentiated lung cancer with metastaes of mediastinum; adenocarcinoma of lung with metastases of bones;poorly differenciated squamous epithelial nasopharyngocarcinoma with metastases of lungs, liver and bones; carcmoma of head of pancreas withmetastasis of liver; Kaposi sarcoma of left thigh with local infiltration; mucinous adenocarcinoma of rectum with metastasis of pelvic cavity. Artificialhematogenous vivax malaria we induced. The courses of treatment were 10~17 fever episodes of malaria. [Results]Partial response(PR) or partialeffectiveness was observed in two patients with adenorinrma of breast and Kaposi areoma respectively. No effect was observed in other 5 cases.[Conclusions]The results from the preliminary studies imply that malariotherapy may be partially detive for some advanced tumor patients who arenaive of chemotherapy and injecting therapy of radioactive isotopes. On the basis of sensitivity - increasing effect of heat on radiotherapy we suggestthat a combination therapy of MT with radiotherapy should be studied in the future.
【Fund】: 美国Rippel基金
【CateGory Index】: R730.5
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【References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Xiao ping, XIAO Bin quan, XU Hui fang, et al. Department of AIDS Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China;Safety and side-effect management of malariotherapy for HIV-infected patients[J];Chinese Journal of Infectious Diseases;2003-04
2 LIU Ying-jie,ZHU Xiao-tong,MA Shi-hong,LI Ji(Department of Pathogen Biology,China Medical University,Shenyang 110001,China);Effect of malariotherapy on the growth of S180 tumor cells[J];Chinese Journal of Zoonoses;2006-10
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Ying-jie,ZHU Xiao-tong,MA Shi-hong,LI Ji(Department of Pathogen Biology,China Medical University,Shenyang 110001,China);Effect of malariotherapy on the growth of S180 tumor cells[J];Chinese Journal of Zoonoses;2006-10
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 Chen Xiaoping, Xiao Binquan , Shi Wenjun , Xu Huifang, et al. Department of AIDS Control and Prevention, Municipal Health and Anti - Epidemic Station of Guangzhou, Guangzhou 510080, Guangdong Province, P. R. China;Impact of vivax malaria on the percentage of apoptotic CD_4 lymphocytes in subjects with HIV/AIDS[J];Journal for China AIDS/STD;2001-02
2 Chen Xiaoping, Xiao Binquan, Shi Wenjun, Xu Huifang, et al. Municipal Health and Anti - epidemic Station of Guangzhou, Guangzhou 510080, Guangdong Province, P. R. China;Indication of Malariotherapy for HIV Infection[J];Journal for China AIDS/STD;2001-04
3 CHEN Xiao-ping,et al.Municipal Health and Anti-epidemic Station of Guangzhou(Guangzhou 510080,China);Impact of HIV Infection Status on Severity of Plasmodium Vivax Malaria[J];China Public Health;2001-12
4 CHEN Xiaoping, XIAO Binquan, SHI Wenjun, et al. Department of AIDS Control and Prevention, Municipal Health and Anti-Epidemic Station, Guangzhou 510080, China;Cytokine responese of HIV-positive patients to acute Plasmodium vivax malaria[J];Chinese Journal of Infectious Diseases;2002-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIU Ying-jie,ZHU Xiao-tong,MA Shi-hong,LI Ji(Department of Pathogen Biology,China Medical University,Shenyang 110001,China);Effect of malariotherapy on the growth of S180 tumor cells[J];Chinese Journal of Zoonoses;2006-10
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