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《Zhejiang Cancer Journal》 2001-02
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Clinical Investigation of Kosam Combined with Chemotherapy to Treat Advanced Malignant Tumors

SHI Lin_hua,QIU You_hao (Zhejiang Cancer Hospital,Hangzhou 310022,China)  
To study the effects and side effects of kosam(Mateling)combined chemotherapy in advanced malignanies. One hundred and twenty_six cases with cancer were randomly divided into two groups,65 cases were Mateling combined chemotherapy (Group A);the other cases were chemotherapy only (Group B).The response rate with group A and B is 48 4% and 39 0% respectively.Neutropenia at Ⅲ~Ⅳ degree was found in 5 cases (7 7%) and 15 cases (24 6%)with group A and B,respectively,and there was significant difference (P0 01)between two groups .The proportion of vomiting and nausea with Ⅲ~Ⅳ degree was 12 3% and 6 2% in group A;57 4% and 42 6% in group B respectively.It was significantly different(P0 01) in 2 groups.The Karnofsky Score improvement was found in 64 6% and 29 5% with group A and group B respectively (P0 01).[Conclusion]Mateling can reduce side effects of chemotherapy and can improve the quality of life.So the combination of Mateling with chemotherapy was safe,feasible and effective in treating the malignant tumors.
【CateGory Index】: R730.5
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