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《Journal of Oncology》 2005-02
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Effects of Matrine on Telomerase Activity and on Proliferation of Human HepG2 and QGY Hepatoma Cell Lines

ZUO Guo-qing, HE Song, ZHANG Yan, et al.(The Second Affiliated Hospital of Chongqing University of Medical Sciences ,Chongqing 400010,China)  
To observe the effects of matrine on proliferation in HepG2 and QGY hepatoma cell lines in vitro. The inhibition of proliferation in HepG2 and QGY cells were estimated by MTT-test. Distribution of cells cycle and apoptosis were analysed by using flow cytometry. The changes of telomerase activity were detected by PCR-ELISA method. Matrine in hibited the proliferation of HepG2 and QGY, which was dose and time dependent. Significant difference was found among groups with different dose and different time(P0.001). Matrine blockod cell cycle and induced cell apoptosis of HepG2 and QGY. Significant difference was found among different groups(P0.001). Matrine inhibited the activity of telomerase, which was dose and time dependent. Significant difference was found among different group(P0.001). [Conclusion] The inhibition of telomerase activity may be one of the mechanisms of the anti-cancer effect of matrine.
【CateGory Index】: R735.7
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