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Effect of glycosides of cistanche on learning and memory in Alzheimer′s disease mice and its mechanism

LIU Feng-xia,WANG Xiao-wen,WANG Xue-fei(Department of Pharmacology,Xinjiang Medical University,Urumqi 830054,China)  
Objective: To observe the effect of cistanche glycosides(GCs) on a model of Alzheimer's disease(AD) in mice and its mechmism. Methods: The AD pathological model was made by intracranial lesions with mini-injection of quinolinic acid.The learning and memory of mice were observed by one time training passive avoidance step-down and Y-maze spatial location task;the acivities of SOD,GSH-Px and TchE,the content of MDA in mice brain were detectced by kits;the apoptosis of bain cells were detected by using TUNEL method and microcope;the content of calcium in AD mice brain was detected by electronic microscope.Results: GGs was shown to improve learning and memory deficiency in mice with brain lesions induced by qunolinic acid.To increase activities of SOD,GSH-Px;to reduce activities of TChE and contents of MDA in mice brain;to decrease apoptosis rate in mice brain cells significantly and to reduce the concentration of calcium in mice brain.Conclusion: The protective effects of GCs on a model of AD in mice may be involved in scavenging free radical,antioxidation,reducing the contents of calcium and inhibition of apoptosis rate in mice brain cells induced by quinolinic acid.
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