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The alteration of serum endotoxin and the influence on cardiac function during liver ischemia reperfusion injury in rats

MA Xiao-juan, WANG Hong-mei, ZHANG Jian-long, et al(Department of Pathophysiology, Xinjiang Medical University, Urumqi 830054, China)  
Objective: To investigate the effect and mechanism of serum endotoxin on cardiac function during liver I/R injury. Methods: Forty eight healthy Wistar male rats were randomly divided into 6 groups as following (n=8): the control group (CTL), simply ischemia 30min without reperfusion (I group), reperfusion following ischemia 30 min (I/R group), 2 hours reperfusion following ischemia 30 min (I/R2h group), 4 hours reperfusion following ischemia 30 min (I/R4h group) and 6 hours reperfusion following ischemia 30min (I/R6h group). The cardiac functions were measured by BL-420 E+ data acquisition and analysis system, including HR, LVSP, LVEDP, ±dp/dtmax. The level of serum endotoxin was measured by kit. Results: During liver I/R injury, HR decreased obviously in the I group and the I/R group (P0.05), but the amount increased gradually with the prolongation of reperfusion, there was no statistic significance compared with CTL (P0.05). The levels of LVSP, LVEDP, ±dp/dtmax were statistic significantly in I/R6h group compared with that of CTL (P0.05). The level of endotoxin reached to peak in I group and I/R group, the amount decreased gradually with the prolongation of reperfusion, but still higher than CTL (P0.05). Conclusion: During the process of liver I/R injury, endotoxin was absorbed from intestine and reducement of hepatic deintoxication led to endotoxemia which plays one of the initial roles in the changes of the cardiac function.
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