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Expression and significance of PPARγin cervical intraepithelial neoplasia and in cervical carcinoma

Axiangu· Hasimu,Lalai· Suzuke,LI Qiao-zhi(Department of Pathology,Xinjiang Medical University,Urumqi 830054,China)  
Objective:To study the expression of PPARγ in cervical intraepithelial neoplasia(CIN),cervical carcinoma and analyze the influence of cervical carcinoma.Method:The expression of PPARγ in 54 patients with cervical intraepithelial neoplasia(CIN),and 43 patients with cervical carcinoma,and 20 patients with normal uteri cervix were served as controls were detected by Envision immunohistological method.Results:The positive rates of PPARγ was 44.12% in CIN Ⅰ-Ⅱ;75% in CIN Ⅲ;88.37% in cervical carcinoma and 5.63% in normal cervix.From chronic cervicitis,cervical intraepithelial neoplasia to cervical carcinoma expression of PPARγ showed an ascending tendency.Compared with those in normal cervical,expression of PPARγ in cervical intraepithelial neoplasia and cervical carcinoma were significantly enhanced(P0.01).Conclusion:Abnormal expression of PPARγ in CIN,cervical carcinoma indicate what were relation of occurring and development,contributing to the invasion of cervical carcinoma,it may be useful to forecast development of cervical carcinoma by examine.
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