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《Journal of Xinjiang Medical University》 2008-07
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The protective effect of 654-2 and Nimodipine to the dysfunction of heart during liver ischemia-reperfusion injury

MA Qi,MA Xiao-juan,HU Zhi-liang,et al (Department of Pathophysiology,Xinjiang Medical University,Urumqi 830011,China)  
Objective: By using Nimodipine and 654-2 pre-treat during the process of liver ischemia-reperfusion injury,to investigate the mechanism of the heart-protection function.Methods: Thirty two healthy wistar rats were randomly divided into 4 groups: control group(CTL),4 hours reperfusion following ischemia for 30 min(I/R4 h),654-2 pre-treat group(I/R4 h+654-2),Nimodipine pre-treat group(I/R4 h+N).To observe the change of those indexes: HR,LVSP,LVEDP,MDA,MPO.Results: LVSP was obviously decreased in I/R4 h group(P0.05),but it obviously increased in I/R4 h+654-2,I/R4 h+N comparing to CTL and I/R4 h group(P0.01);LVEDP obviously decreased in I/R4 h+654-2 and I/R4 h+N compared to CTL and I/R4 h group(P0.01);the level of MDA obviously increased in I/R4 h group,there was significant difference compared with CTL(P0.01),there was also an obvious significant difference in I/R4 h+654-2 and I/R4 h+N compared to CTL and I/R4 h group(P0.01);the level of MPO obviously increased in I/R4 h+654-2(P0.01),but there was no significant difference compared with I/R4 h group(P0.05),there were significant differences between I/R4 h+N and CTL,I/R4 h group(P0.01).Conclusion: During the process of dysfunction of heart induced by liver ischemia-reperfusion injury,the protective effect of Nimodipine to the heart is better than that of 654-2.
【CateGory Index】: R96
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