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《Journal of Xinjiang Medical University》 2011-01
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Protection effects of grape-seed proanthocyanidins extrac on renal ischemia reperfusion injury in rats

WANG Lei,Mamatzunun·Mansur,Kelala·Abasi,et al(Department of Pathophysiology,Preclinical Medical College,Xinjiang Medical University,Urumqi 830011,China)  
Objective To investigate the anti-oxidation effects of grape-seed proanthocyanidins extrac(GSPE) on Renal Ischemia Reperfusion Injury in Rats.Methods Thirty-six Wistar rats(180~220 g) were divided into three groups with 6 rats in each randomly: sham operation group(Sham group),renal ischemia reperfusiona injury group(RIRI group),grape seed proanthocyanidins group(GSPE group).The content variation of serum creatinine(Scr),blood urea nitrogen(BUN) in plasma,the content variation of MDA in plasma and tissue and the activity variation of GSH-Px in plasma and tissue were detected respectively in renal ischemia-reperfusion at 2 h and 24 h.Results Compared with the Sham group,the contents of Scr,BUN in plasma and MDA in plasma and tissue were significantly higer in RIRI group and GSPE group(P0.05),and activity of GSH-Px was lower in RIRI group and GSPE group(P0.05);Compared with the RIRI group,the contents of Scr,BUN were lower in grape seed proanthocyanidins group,the contents of MDA in plasma and tissue were also lower(P0.05);the activity of GSH-Px increased significantly(P0.01),and GSPE 2 h group had no significant difference compared with GSPE at 24 h.Conclusion The GSPE played a protective role on the kidney in the process of renal ischemia reperfusion injury,the mechanism may be related to anti-free radical injury and reduce the lipid peroxidation.
【CateGory Index】: R285.5
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