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《Journal of Xinjiang Medical University》 2011-12
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Acute toxicity and long-term toxicity study on Abnormal Savda Munziq

Abdiryim Yusup1,Guzalnur Imam1,Mahsum Hekim1,Anwar Hekim2,JI Zhi Hong3,LI Xue Jun3,Aynur Matsidik1,Halmurat Upur1(1Faculty of Traditional Uighur Medicine,Xinjiang Medical University,2College of Pharmacy,Xinjiang Medical University,Urumqi 830011,China;3Xinjiang QiKang HaBo Uighur Medicine Farmuceutical Limitied Cooperation,Urumqi 830026,China)  
Objective To study the acute toxicity in mice and long-term toxicity in rats of abnormal savda munziq granular to evaluate the clinical safety of medication and develop clinical trials dose and the observed indicators.Methods Acute toxicity observation: Mice were given intragastric administration twice a day,acute toxicity of abnormal savda munziq granular on 14 days after the administration was observed,LD50 was detected.Long-term toxicity observation: doses of gbnormal savda munziq granular were 3.75,7.5,15.0 g·kg-1·d-1 and equal-volume 5% carboxymethylcellulose sodium suspension was given to control group they were administered 6 days perweek,for180 d,with continuous oral administration for 90 d,180 d and without given the abnormal savda munziq granular for 30 days,straight rats appearance,behavior,body weight,food in take,hematology and blood chemistry were detected in various indicators and delivery and recovery were conducted after the end of pathological examination.Results Acute toxicity observation: the mice were all survived and LD50 was not measured and the largest amount of drug was 200 times of clinical dose administration.Long-term toxicity observation: Changes in the body weights,the relative organ weights,the food in takes were not significantly demonstrated in all groups throughout the study.In addition,indices of the hematology and the blood chemistry were in normal range,no histopathological lesions were observed in the animals.Conclusion The abnormal savda munziq granular isn't found long-term toxicity and acute toxicity in this experiment condition,it suggested savda munziq granular has a good clinical safety.
【Fund】: 新疆维吾尔自治区科技攻关和重点计划项目(编号:200733146-4)
【CateGory Index】: R285.5
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