Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Xinjiang Medical University》 1998-02
Add to Favorite Get Latest Update

Determination of Anisodamine Hydrochloride and its Pharmacokinetic Parameters by RP HPLC

He Xin, Chen Jian Department of Pharmacy, Xinjiang Medical College  
Objective: To build a rapid method for the separation and determination of anisodamine hydrochloride in rabbit's serum, and determining the pharmacokinetic parameters after iv or ig Ani and its absolute bioavailability in rabbit. Methods: Determining the serum concentration of Ani in rabbit by reversed phase HPLC and UV detector at 214 nm, CH 3OH H 2O (C 2H 5) 3N(30∶70∶0.125) as mobil phase, atropine sulfate as an internal standard. Calculation of the pharmacokinetic parameters by using a NLFT.ZHU program on microcomputer. Results: A two compartment open model featured the pharmacokinetic process after iv or ig Ani in rabbits, belong to fast distribution drug, absolute bioavailability is 6.36%. Conclusions: A rapid, sensitive and precise method for the separation and determination of Ani by RP HPLC has been developed and optimized. The pharmacokinetic process after iv or ig Ani in rabbits has been expounded.
【CateGory Index】: R969.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 SUN Kai,YANG Li-min (Department of Pharmacy,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China);Advance in pharmacological and clinical research of anisodamine[J];World Clinical Drugs;2010-03
2 CHEN Huai-xia,CHEN Yong(Hubei Province Key Lab of Bio-Technology of Traditional Chinese Medicine,Hubei University,Wuhan 430062);Analysis of anisodamine and its metabolites in homogenized liver of rat by liquid chromatography-tandem mass spectrometry[J];Journal of Hubei University(Natural Science);2006-03
【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHAN Li-fen, ZHANG YU-zhi, HE Mei-sheng (Dept Pharmacology, The China Medical University, Shenyang 110001);Determination of apparent pharmacokinetic parameters of anisodamine by acute mortality of mice[J];Chinese Journal of Pharmacology and Toxicology;1987-02
2 Xie Jingxi, Zhou Jin, Jia Xiaoxian and Liu Chunxue. (Institute of Materia Medica, Chinese Academy of Medical Sciences Beijing) XU Huiqin, Fang Anshi, Wang Jinzhi and Xia Boyang (Beijing Pharmaceutical Factory);STUDIES ON THE SYNTHESIS OF ANISODAMINE[J];Acta Pharmaceutica Sinica;1980-07
3 P Ma;CY Wu School of Pharmacy,West China University of Medical Sciences,Chengdu 610041;STUDIES ON THE DETERMINATION OF PLASMA LEVEL AND PHARMACOKINETIC PARAMETERS OF ANISODAMINE BY MICELLAR LIQUID CHROMATOGRAPHY[J];Acta Pharmaceutica Sinica;1992-10
4 Zhan Lifen, et al (Department of Pharmacology);THE COMPARISON OF PHARMACOKINETIC PARAMETERS OF ANISODAMINE WITH THE METHODS OF DETERMINATION OF BLOOD CONCENTRATION AND TOXICOLOGICAL EFFECT[J];Journal of China Medical University;1989-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Li et al(College of Material and Chemical Engineering,Sichuan University of Science & Engineering,Zigong,Sichuan 643000);Study on Ultrasonic-microwave Synergistic Extraction of Total Flavonoids from Morus alba L.Leaves[J];Journal of Anhui Agricultural Sciences;2010-17
2 JIANG Qin et al(Horticultural Institue,Anhui Academy of Agricultural Science,Hefei,Anhui 230031);Study on Rapid Propagation Technology for Tissue Culture of Dendranthema morifolium (Ramat.) Tzvel. 'Boju' cv. nov.[J];Journal of Anhui Agricultural Sciences;2010-34
3 KAI Xiao ming (The Chem.Dept.of Anqing Normal College,Anqing 246011,China);A Accuracy investigation of second derivative method to determine an end point of weak acid-Bases potentiometric titration[J];Journal of Anqing Teachers College(Natural Science Edition);2001-02
4 Shen Naikui, et al. (Department of Chemistry, Bengbu Medical College, Anhui );STUDY ON THE NEW METHODS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF VITAMIN C——2; 4-Dinitrophenol as chromogenic reagent[J];Journal of Bengbu Medical College;1986-01
5 HE Wei-qiang,XIANG Tian-yong,TAO Kun(Jiaxing Vocational Technical College,Jiaxing,Zhejiang 314036);Resarch Advances on the Pharmacological Function of Mulberry Leaf Active Constituent[J];Northern Horticulture;2011-23
6 Yu Kongting,Hao Xinmin,Ma Jun (Duanzhou People's Hospital of Guanfdong Province Zhaoqing,Zhaoqing 526040,China);An Improvement on the Assay Method Calcium、Magnesium in the Dialysis Solution for Artificial Kidney[J];Journal of Baotou Medical College;2002-01
7 Former Basic Chemistry Teaching Group, Faculty of Pharmacy Department of Industrial Hygiene, Faculty of Public Health, Beijing Medica1 College;THE SYNTHESIS OF AN ANTI-SILICOSIS DRUG——ALUMINIUM CITRATE COMPLEX[J];;1980-01
8 WEI Yun(Mianyang city,Sichuan Province Institute for Food and Drug Control,Mianyang 621000;Sichuan);Study on Quality Standard of Hemsleya Amabilis[J];Journal of Chengdu University of Traditional Chinese Medicine;2011-03
9 Gu Hongyu, Wang Zunyao (Yancheng Institute of Technology,Jiangsu 224003);Rapid Measurement of Sulfate Radical Content in Different Waters in the Method of Conductometric Titration[J];CHONGQING ENVIRONMENTAL SCIENCE;1997-04
10 Yang Yuru Chen Xiaofu Luo Guoxian Department of Chemistry, Hangzhou Teacher's College, Hangzhou 310012;Determining Cyameluric Acid Content by Making a Chart with Inverse Logarithm[J];;1993-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Ma Liping, Zhang Guoyuan, Hou Jian, Wu Zonggui, Ding Siqi (Department of Cadiovasology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003);Effects of interleukin 6 and tumor necrosis factor on cultured vascular endothelial cells[J];Academic Journal of Second Military Medical University;1999-02
2 Xie Jianjun, Yao Xiujuan, Xhao DehuaDepartment of Pharmacology, Fourth Military Medical University, Xi'an 710033;The effects of anisodamine on postburn hemorrheology in rats[J];Journal of The Fourth Military Medical University;1997-01
3 SUN Jun, YAO Xiu Juan, ZHAO De Hua Department of Pharmacology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China;Inhibitory effects of anisodamine on lipopolysacchrides attaching to endothelium and inducing NO release[J];Journal of The Fourth Military Medical University;2001-12
4 JIANG Zidong LIU Wen ZHAO Cuixia ZHANG Lianshan (Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing,100730,China);Adjuvant treatment of anisodamine to acute serous otitis media[J];Journal of Clinical Otorhinolaryngology;2004-07
5 Zhou Hongbing;Zhang Xuan and He Xin (Department of Pharmacy , Xinjiang Medical College,Urumqi,830054);Determination of Anisodamine Hydrochloride in Serum of Rabbit by High Performance Liquid Chromatography (HPLC)[J];CHINESE JOURNAL OF CHROMATOGRAPHY;1996-01
6 Xu Yumin; Zhao Nanming (Department of Biological Sciences & Biotechnology Tsinghua University);THE SMALL ANGLE X-RAY DIFFRACTION FOR DETERMINING THE INTERACTION OF ANISODAMINE MOLECULES WITH MEMBRANE STRUCTURES[J];Acta Biophysica Sinica;1991-03
7 Liu Fengsong; Wang Pingyuan; Chen Jianwen; Hwang Fen(National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, Beijing , 100101)(This project was supported by National Nature Science Foundation of China.);ANISODAMINE CAUSES ACYL CHAIN INTERDIGITATED GEL PHASE IN DPPG/DPPC MIXTURE ──THE STUDY OF FLUORESCENCE POLARIZATION[J];ACTA BIOPHYSICA SINICA;1994-04
8 FANG Cai yun, QIAO Fu yuan, FANG Xiao mei. Department of Obstetrics and Gynecology, The Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Techology, Wuhan ,430030,China;Role of soluble vascular cell adhesion molecole 1, interleukin 6 and tumor necrosis factor-αin the pathogenesis of pregnancy induced hypertension syndrome[J];The Journal of Practical Medicine;2005-02
9 DING Guixia,CHEN Ronghua △,ZHANG Aihua △,WU Yuanjun △,PANG Xiaoqin △ The Second Affiliated Hospital of Nanjing Medical University,Nanjing,210011 △ Center of Pediatric Nephrology,Nanjing Medical University,Nanjing,210029;Effect of NF-κB antisense oligodeoxynucleotide on the expression of pro-inflammatory cytokines,chemokines,and pro-fibrogentic in human mesangial cells[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2002-02
10 Yan Goudong Zhou Wenhua,et al.(Ningbo microcirculation & herb drugs institute,Ningbo 315010);Effect of Anisodamine on the fluidity of erythroyte membrane and the intrinsic fluorescence of ghost[J];;1993-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Liu Dongming and Yun Cailin;Progress in the Research of Pharmacology of Active Ingredients in Common Physochlaina[J];Journal of North Pharmacy;2007-06
2 Yang Shuying,Shan yan(Nursing College of Zhengzhou University,Henan 450052 China);Research progress on wound surface care of patients with diabetic foot[J];Chinese General Practice Nursing;2011-35
3 PAN Zhen-yu,GAO Guan-qi,LIAO Lin(Shandong Medical College,Linyi,Chian 276002);EARLY DIABETIC LOWER EXTREMITY ARTERIAL DISEASE TREATED WITH INTRAFEMORAL INJECTION OF ANISODAMINE[J];Journal of Shandong Medical College;2006-06
4 HE Zhi-jie, LIN Xiao-hong, HUANG Zi-tong Department of Emergency, the 2nd Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120;Clinical Study of Penehyclidine Hydrochloride on Patient with Septic Shock[J];Lingnan Journal of Emergency Medicine;2006-06
5 CHEN Liang1,JIANG Jin-qi1,ZHANG Dao-liang1,YANG Shun-fang2(1.Department of Emergency,2.Department of Nuclear Medicine,Shanghai Chest Hospital,Shanghai Jiaotong University,Shanghai 200030,China);Experimental observation on treatment of coronary microcirculatory disturbance by anisodamine[J];Journal of Shanghai Jiaotong University(Medical Science);2010-06
6 ;盐酸戊乙奎醚注射液改善休克微循环的对比研究[J];Chinese Journal of Practical Internal Medicine;2008-10
7 WANG Wen1,WU Ting-ting1,WANG Xiao-juan1,WEI Jing-jing1,XIE Yun1,WANG Tong2,ZHANG Li-cai1,3(1.Dept of Anesthesiology,Xuzhou Medical College,Xuzhou Jiangsu 221002,China;2.Xiangya School of Medicine, Central South University,Changcha 410013,China;3.the Key Anesthesiology Laboratory of Jiangsu Province Jiangsu Province Key Laboratory of Anesthetic and Analgesic Application Technology,Xuzhou Medical College,Xuzhou Jiangsu 221002,China);The influences of anisodamine on the hypnosis and analgesia of diazepam treated mice[J];Chinese Pharmacological Bulletin;2011-02
8 LING Xiao,XU Zhi-zhou(Institute for Drug Control,Jinan 250101,China);HPLC determination of raceanisodamine hydrochloride injection and its related substances[J];Chinese Journal of Pharmaceutical Analysis;2011-10
9 YANG Hai-tao,TANG Li-hua,ZHOU Feng.Department of Aneathesia,The Second Hospital Dalian Medical University,Dalian 116023,China;Clinical Effects of Preoperative Penehyclidine Hydrochloride in Patients with Septic Shock[J];Medicine & Philosophy(Clinical Decision Making Forum Edition);2011-07
10 MA Xiao-hong,WANG Xin-li,CHEN Yong,HAN Feng-mei (Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine,Hubei University,Wuhan 430062,China);Determination of anisodamine in plasma of rat by HPLC-MS[J];Chinese Traditional and Herbal Drugs;2008-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAN Li-fen, ZHANG YU-zhi, HE Mei-sheng (Dept Pharmacology, The China Medical University, Shenyang 110001);Determination of apparent pharmacokinetic parameters of anisodamine by acute mortality of mice[J];Chinese Journal of Pharmacology and Toxicology;1987-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved