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《Journal of Xinjiang Medical University》 1998-02
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Determination of Anisodamine Hydrochloride and its Pharmacokinetic Parameters by RP HPLC

He Xin, Chen Jian Department of Pharmacy, Xinjiang Medical College  
Objective: To build a rapid method for the separation and determination of anisodamine hydrochloride in rabbit's serum, and determining the pharmacokinetic parameters after iv or ig Ani and its absolute bioavailability in rabbit. Methods: Determining the serum concentration of Ani in rabbit by reversed phase HPLC and UV detector at 214 nm, CH 3OH H 2O (C 2H 5) 3N(30∶70∶0.125) as mobil phase, atropine sulfate as an internal standard. Calculation of the pharmacokinetic parameters by using a NLFT.ZHU program on microcomputer. Results: A two compartment open model featured the pharmacokinetic process after iv or ig Ani in rabbits, belong to fast distribution drug, absolute bioavailability is 6.36%. Conclusions: A rapid, sensitive and precise method for the separation and determination of Ani by RP HPLC has been developed and optimized. The pharmacokinetic process after iv or ig Ani in rabbits has been expounded.
【CateGory Index】: R969.1
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