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《RECENT ADVANCES IN OPHTHALMOLOGY》 1998-03
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Clinical study on tetramethlprazine for treating the diabetic retinopathy

DQU Jing-Fang;WENG Xiao-Gang(The Third and First Affiliated Hospital of Xinxiang Med ical College. Xinxiang; Henan Province 453003, China)  
Objective To research foe therapecutic effects of tetramethelprazine (TMPZ) for diabetic retinopathy (DR).Methods Of 87 cases of DR patients. 166 eyes were divided into two groups randomly: the control group and the therapeutic group. Besides the routme treatment,280-400mg (5mg·kg 1 body weight )TMPZ was added to the intravenous drop each day for every patient in the therapeutie group. The duration of one course was two weeks and all the patients were treated for 3 courses. Before and after treatment,the plasma sugar, blood rheology and microcircullation of the patients in these two groups were assayed.The t test and X2 test were used for statistical analysis.Results Compared with the control group, TMPZ treatrment can improve the retinopathy and enhance the visual acuity more significantly. The notable effective rate (22.22%) and the total effective rate (68. 69% ) of the therapeutic group are higher significantly than those of the control group, (10. 45 %. P0. 025; 38.81%, P0. 005respectively ). TMPZ can also improve the abnormal blood rheologic inderes and microcirculation in therapeutic group patients.Conclusion TMPZ has a significant effect for DR,especially for the simple DR patients.
【CateGory Index】: R771.3
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