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《Recent Advances in Ophthalmology》 2008-02
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Ligustrazine on ocular endosmosis of ciprofloxacin in rabbit eyes of corneal perforating injury

ZHOU Bei,LIN Xiao-Feng,WU Wei,YE Mao-Guo,HU Dong-Mei,LI Qing From the Department of Ophthalmology,Tianhe Central Hospital(ZHOU Bei,YE Mao-Guo,HU Dong-Mei),Guangzhou 510655,Guangdong Province,China;Zhongshan Ophthalmic Center,Sun Yat-sen University(LIN Xiao-Feng,WU Wei,LI Qing),Guangzhou 510060,Guangdong Province,China  
Objective To investigate the changes of blood-ocular barrier and effect of ligustrazine on the ocular endosmosis of intravenous ciprofloxacin in rabbit eyes of corneal perforating injury.Methods Eighteen New Zealand rabbits were randomly divided into 3 groups.Group A and B received surgically corneal perforating injury to each eye.After 1 hour,each rabbit received intravenous infusion of ciprofloxacin in group A and intravenous infusion of ciprofloxacin following ligustrazine in group B.Group C served as control group with only intravenous infusion of ciprofloxacin.Ciprofloxacin concentration of aqueous humor and vitreous body was measured 0.5 hour after the intravenous injection by reversed phase high performance liquid chromatograph(RP-HPCL)and the protein concentration of aqueous humor was measured with biuret conorimetric method simultaneously in all eyes.Results The protein concentrations of aqueous humor in experimental groups (group A and B)were,(11.977±5.774)g·L-1 and(14.767 ±5.814 )g·L-1,significantly higher than that of control group,(2.741±1.193)g·L-1(P0.01).The ciprofloxacin concentration of aqueous humor in experimental groups (group A and B) were,(1.390±0.284)mg·L-1 and(1.390±0.284)mg·L-1,significantly higher that of control group,(0.655±0.291)mg·L-1.There was positive correlation between protein concentration and ciprofloxacin concentration in group A and B(P0.01),but no significant difference (P0.05).The ciprofloxacin concentrations were(0.073±0.059)mg·L-1,(0.085±0.041)mg·L-1 and (0.064±0.051)mg·L-1 in group A,B and C,respectively.Conclusion The permeability of blood-retina barrier is increased after Perforating corneal trauma,which results in increased ciprofloxacin concentration in aqueous humor.Ciprofloxacin levels of aqueous humor after intravenous injection are above the minimum inhibitory concentration (MIC90) for most of the common microorganisms causing endophthalmitis.Ligustrazine is unable to increase the intraocular permeability of ciprofloxacin and can be used to improve blood circulation in eye of corneal perforating injury.
【Fund】: 广东省中医药管理局经费资助(编号:1050065)~~
【CateGory Index】: R285.5
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