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《The Chinese Journal of Human Sexuality》 2013-04
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Prenatal serum screening:an analysis on the results of 3142 patients

YANG Xiuping1,ZHAO Jianpeng2,GAO Xia1,LI Tianjun2 Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou,075000 China  
Objectives: To screen Down’s syndrome and the related disease by detecting maternal mid-pregnancy serum alpha-fetoprotein(AFP),human chorionic gonadotropin beta subunit(Free β-HCG),free three female alcohol(uE3),combining with B ultrasound and amniotic fluid chromosome examination.Methods: Determination of AFP,Free β-HCG and uE3 quantity by DELFIA kits provided by the Finland Wallac Company.Results: Among the 3142 cases,196 cases were found out to be at high risk through the second trimester maternal screening,including 132 cases at high risk of Down’s syndrome,33 cases of 18-trisomy,31 cases of neural tube defects.Pregnant women under 35 years old were at lower risk that those who were over 35.Among 98 cases which took amniotic fluid chromosome examination,2 cases of Down’s syndrome were found out.One case was diagnosed as myelomeningocele by doing B ultrasound.Conclusion: It is of great importance to perform mid trimester prenatal screening so as to prevent and reduce born defects.
【CateGory Index】: R714.5
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