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《Chinese Journal of Human Sexuality》 2018-01
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Effects of intrauterine infection on IL-1,IL-6,IL-8,IL-10 and TNF-alpha in preterm infants

GUO Linqiong;LIU Junli;JI Ting;LIU Xing;Department of Obstetrics,Northwest Women and Children's Hospital;  
Objectives: To investigate the effect of intrauterine infection on IL-1,IL-6,IL-8,IL-10 and TNF-alpha in premature infants. Methods: Retrospective analysis of the clinical data of preterm infants with intrauterine infection in our hospital from August 2015 to October 2016 was done. Preterm infants without intrauterine infection in our hospital in the same period were selected as control group. The serum levels of inflammatory cytokines,NIHSS score,renal function,myocardial enzymes and the general condition of two groups were observed.Results: The levels of IL-1,IL-6,IL-8,IL-10 and TNF-alpha in study group were significantly higher than these in control group( t = 7. 044,12. 208,7. 289,20. 185,5. 421,P 0. 001). The SpO_2 and PaO_2 in study group were lower than those in control group( t =-6. 353,-35. 142,P 0. 001). Pa CO2 level in study group was higher than that of control group( t = 35. 720,P 0. 001); The NIHSS score in study group was higher than that in control group( t = 50. 424,P 0. 001),and the Apgar score of 1 min and 5 min in study group was lower than that of control group( t =-3. 475,-4. 398,P 0. 001); The levels of urea nitrogen,creatinine and CK-MB in study group were higher than these in control group( t = 49. 014,11. 611,16. 458,P 0. 001); Pearson correlation analysis showed that the levels of serum IL-1,IL-6,IL-8,IL-10 and TNF-alpha were positively correlated with NIHSS score,renal function and myocardial enzyme level,and negatively correlated with Apgar score. Conclusion: The levels of IL-1,IL-6,IL-8,IL-10 and TNF-alpha are higher in preterm infants with intrauterine infection,which are closely related to the NIHSS score,renal function and myocardial enzymes.
【CateGory Index】: R722.6
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