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《Advances in Psychological Science》 2013-09
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Gender Differences in the Genetic Underpinning of Depression

CAO Yanmiao;WANG Meiping;CAO Cong;CHEN Guanghui;ZHANG Wenxin;School of Psychology, Shandong Normal University;  
Human depression has complex genetic underpinnings which vary across genders.These gender differences exist both in forms of direct effects of genes and gene-environment interactions on depression.The present paper systematically reviewed the extant literature of both twin studies and molecular genetic studies in the realm and discussed the possible causes of gender differences in the association between genetic variants and depression.Possible explanations provided included gender differences in sex hormones,sensitivity to environment and intermediate phenotype.Previous studies have highligted the value in taking a developmental perspective in investigating genetic effects on depression,future research should employ longitudinal design to reveal the developmental changes of the effect of genetic variants and their interactions with enviroment on depression.Besides,gender differences in genetic susceptibility to depression remain an important direction for future research.
【Fund】: 国家自然科学基金项目(31271105);; 山东省自然科学基金项目(ZR2010CM006);; “十二五”强化建设重点学科(发展与教育心理学)建设经费资助项目;; 山东师范大学心理学院青年教师研究创新计划项目
【CateGory Index】: B842.6
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