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A STUDY ON TOXICITY OF OXYTROPIS OCHROCEPHALA IN GOATS

Wang Kai ( Oinghai Animal Science and Veterinary Medicine College ) Cao Guangrong, Duan Dexian, Li Shaojun, Gao Juxing ( Northwestern University of Agriculture )  
10g/kg B.W/day Oxytropis ochrocephala power was given to 5 goats via permanent fistula of the rumen, respectively, for study the toxicity of Oxytropis ochrocephala in goats. On the 18-22th day of test, goats appeared neural signs: depression, staring eyes, ataxia, leg weakness, hind quarter paralysis, recumbency and oliguria.On the 33-65th days, the goats died.In lab examinations, liver function tests showed obvious changes: the GOT activity and icterus index in serum increased, α-mannosidase activity in plasma decreased'oligosaccharide excretion increased in urine. Alkaloids was found in urine, MHb and GSH-peroxidase in blood did not change. The major patho-histological lesions were vacuo-lar degeneration in cerebellum Purkinje and Pancreas gland cells, and granular degeneration in hepatic and renal tubular epithelial cells. The results of experiment eliminate the possibility that Oxytropis ochroceph-ala poisoning was due to its excessive selenium and aliphatic Nitro-compounds, and proved that the toxic principles of Oxytropis ochrocephala might be indolizidine alkaloid.lt is assumed that the key factor of poisoning is the activity of α-mannosidase suppressed by the alkaloid.
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