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《CHINESE JOURNAL OF ANIMAL AND VETERINARY SCIENCES》 2000-05
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EFFECTS OF THE ANTI ABORTIFACIENT CHINESE HERBAL MEDICINE RADIX SCUTELLARIAE AND RHIZOMA ATRACTYLODIS ON LPS INDUCED ABORTION AND UTERINE CONTENTS OF TNF α IN MICE

Zhong Xiuhui,Zhou Zhanxiang,Sun Binggui,Deng Zepei,Liu Jiwu (College of Veterinary Medicine,China Agricultural University,Beijing 100094,China) [WT5HZ]  
WT5BZ]In order to investigate the significance of the Th1 cytokine TNF α in abortion and the anti abortifacient mechanisms of the Chinese herbal medicine Radix scutellariae and Rhizoma atractylodis ,Lipopolysaccharide(LPS)was injected iv.via the tail vein(0.1 μg per mouse)to induce abortion in kunming mice.The TNF α contents in the uterus were assayed by ELISA.The results revealed that the TNF-α level was significantly elevated in LPS induced abortions in comparison with the controls.The combined decoction of Radix scutellariae and Rhizoma atractylodis given orally to the pregnant mice prior to LPS treatment significantly inhibited the abortifacient effect of LPS.These findings suggest that LPS induced abortion is associated with the TNF α production in the uterus,and that the anti abortifacient effects of the two Chinese medicinal herbs are realized through modulation of the TNF-α secretion at the maternal fetal interface.
【Key Words】: Chinese herbal medicine Reproductive immunology Abortion LPS TNF-α
【Fund】: 国家自然科学基金! (39770 5 43);; 河北省自然科学基金! (3991 31 );; 北京市自然科学基金资助! (6 982 0 1 4 )
【CateGory Index】: S853.7
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