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《Chinese Journal of Animal and Veterinary Sciences》 2004-06
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Toxicity Study of Oxytropis glacialis in Rabbits

LI Qin-fan, WANG Jian-hua, GENG Guo-xia, YAN Xiao-bing, WANG Xiao-ting(College of Animal Science and Technology, Northwest Science and Technology University of Agriculture and forestry, Yangling 712100, China)  
Seventeen rabbits were divided into control group (n=6) and experimental group (n=11). In the experimental group, rabbits were fed with Oxytropis glacialis of 10 g/kg each day. On the 0,7,14,21,28,35,42,47,56,63 day of feeding, blood biochemical indexes were measured respectively. The results indicated that the activities of serum AKP, GOT and BUN value of poisoned rabbits were significantly higher than that of control group (P0.05 or P0.01), while serum α-mannosides activity significantly lower than that of control group (P0.01). There were neither significantly difference in serum total protein, nor globulin and albulin between the two groups (P0.05). Lymphocyte occurred vacuolation in the blood from 4~(th) day. Histopathological examination showed that heart, liver, spleen, lung and kidney were all vacuolized. These results proved that heart, liver, kidney and other viscera were damaged by the toxin of Oxytropis glacialis. Compared with published data, rabbit have better ability to bear the toxin of Oxytropis glacialis than some other animals.
【Fund】: 国家自然科学基金项目(30070577)
【CateGory Index】: S859.82
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