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《Chinese Journal of Animal and Veterinary Sciences》 2010-06
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Effect of Dietary High Molybdenum on the Cell Cycle and Apoptosis of Thymus in Broilers

YANG Fan, CUI Heng-min, XIAO Jie, PENG Xi, CUI Wei, CHENG An-chun, CHEN Tao, BAI Cai-min (Key Laboratory of Environmental Hazard and Animal Diseases of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya′an 625014, China)  
The experiment was conducted with the objective of examining the effects of high molybdenum on the thymus in the broilers by the methods of experimental pathology and flow cytometry(FCM).360 one-day-old Avian broilers were randomly divided into four groups,and fed on diets as follows:Control diet (Mo 13 mg·kg-1) and High molybdenum diets(Mo 500 mg·kg-1, High molybdenum groupⅠ; Mo 1 000 mg·kg-1, High molybdenum groupⅡ; Mo 1 500 mg·kg-1, High molybdenum group Ⅲ) for 6 weeks. The results showed that decreased lymphocytes, enlarged Hassall′s corpuscles and increased myoid cells were observed in high molybdenum groupsⅠ,Ⅱand Ⅲ in comparison with those of control group histopathologically. The weight and the relative weight of thymus were decreased. The statistical analyses by FCM indicated that the G0/G1 phase of thymocyte was increased (P0.05 or P0.01) and the G2+M phase, S phase of thymocyte and the PI (Proliferating index) were decreased (P0.05 or P0.01) in high molybdenum groupsⅠ,Ⅱ and Ⅲ. Meanwhile, the percentage of cellular apoptosis was higher in high molybdenum groupsⅠ,Ⅱ and Ⅲ than that in control group. Also, the TUNEL staining was consistent with the result of FCM. It was concluded that dietary molybdenum in excess of 500 mg·kg-1 inhibited the development of thymus, caused pathological changes in the thymus and impaired the function of cellular immunity in broilers.
【Key Words】： high molybdenum thymus cell cycle apoptosis broilers
【Fund】： “教育部长江学者和创新团队发展计划”创新团队项目(IRT0848);; 四川省重大培育项目;; 四川省科技厅基础应用研究项目;; 四川省教育厅重点项目;; 四川农大“双支”计划创新团队项目
【CateGory Index】： S831
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