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《Chinese Journal of Animal and Veterinary Sciences》 2010-12
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Effect of High Molybdenum on the Pathologic Lesion and Antioxidative Function of Kidney in Broilers

XIAO Jie,CUI Heng-min*,YANG Fan,PENG Xi,CUI Wei,CHENG An-chun,CHEN Tao,BAI Cai-min(Key Laboratory of Environmental Hazard and Animal Diseases of Sichuan Province,College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China)  
300 one-day-old Avian chicks were randomly divided into four groups and feed on diets as follows:control diet(Mo 13 mg·kg-1) and high molybdenum(Mo) diets(Mo 500 mg·kg-1,high molybdenum group Ⅰ;Mo 1 000 mg·kg-1,high molybdenum group Ⅱ;Mo 1 500 mg·kg-1,high molybdenum group Ⅲ) for 42 days,examining the effect of dietary high molybdenum on pathologic lesions in kidney of broilers.Compared with those of control group,the renal tubule epithelial cells showed swelling,granular degeneration and vacuolar degeneration in high Mo groups.Ultrastructurally,endoplasmic reticulum and nuclear membrane expanded,mitochondrial were swelling or loss of volume and increases in electron density,and myelin-like structure in the microvilli were appeared in renal tubule epithelial cells in high Mo groups.The renal glutathion peroxidase(GSH-Px) and superoxide dismutase(SOD) activities were lower(P0.01),and the malondialdehyde(MDA) contents were higher(P0.01) in high Mo groups Ⅱand Ⅲ than that in control group.Changes of the above mentioned enzymes activities and MDA contents in serum were consistent with those of kindey.At the same time,the serum creatinine and serum uric acid contents were much higher in high Mo groups Ⅱand Ⅲ than that in control group(P0.05 or P0.01).The results showed that dietary molybdenum in excess of 1 000 mg·kg-1 caused renal pathological injury and decreased antioxidant enzymes activities.The renal function was finally injuried.
【Fund】: “教育部长江学者和创新团队发展计划”创新团队项目(IRT0848);; 四川省重大培育项目(09ZZ017);; 四川省科技厅基础应用研究项目;; 四川省教育厅重点项目;; 四川农大“双支”计划创新团队项目
【CateGory Index】: S858.31
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