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《Chinese Journal of Animal and Veterinary Sciences》 2011-08
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Effect of Gaoqin Oral Liquid on LPS-induced Fever in Minipigs

YUN Shui1,LIU Feng-hua1,XU Jian-qin2,LIU Qiu-dong1,WU Ju-fu1,WU Guo-juan1,ZHANG Zhong-wen1 (1.Beijing University of Agriculture,Beijing 102206,China;2.China Agricultural University,Beijing 100193,China)  
This study was conducted to the effects and mechanisms of Gaoqin oral liquid(GOL) on LPS-induced fever in minipigs.Forty minipigs were randomly allotted into four groups: Control group,Model group,Dipyrone group and GOL group.There were six minipigs in each group.Fever model in minipigs was reproduced by peritoneal injection of LPS 80 μg·kg-1 twice and there was 12-hour interval.6 h after LPS was injected,Control group and model group were drenched with saline,intravenous injection(IM) was used to give dipyrone in Dipyrone group,GOL group was drenched with GOL,one time a day and 3 days continuously.The basal body temperature was measured before LPS was injected and then 6 h later,we made the administration,the rectal temperatures were measured at the point of 1,3,5,24,30,42 and 54 h after the first administration.Change of clinical symptoms were observed and scored.54 h after administration,6 blood samples were collected in each group from precaval vein,TNF-α,IL-1,cAMP and PGE2 in blood serum were measured.The results showed that,compared with model group,clinical symptoms of GOL group were significantly improved;compared with the control group,IL-1,TNF-α and PGE2,cAMP of model group were significantly increased(P0.05);compared with model group,GOL significantly lowered the levels of TNF-α,cAMP and PGE2(P0.05),but have no significant effect on IL-1 levels(P0.05).The above results suggest that GOL significantly inhibited LPS-induced fever in minipigs.Antipyretic effect may be related to the inhibition of TNF-α in blood serum,and reduce the release of PGE2 and cAMP.
【Fund】: 北京市自然科学基金(5102014);; 国家“十二五”科技支撑计划重点项目(2011BAD34B01);; 北京市教委科技项目(KM201010020008);; 国家自然科学基金(30972215)
【CateGory Index】: S858.28
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