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《Chinese Journal of Animal and Veterinary Sciences》 2013-07
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Effect of Xijiao Dihuang Decotion on IL-1β and PGE_2 in Lipopolysaccharide-induced Fever in Rats

DONG Hong,ZHANG Tao,HU Ge,JIANG Dai-xun,WANG Jian-fang,LI Jia,MU Xiang*(Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Department of Animal Science and Technology,Beijing University of Agriculture,Beijing102206,China)  
The aim of this study was to investigate the effect and mechanisms of Xijiao Dihuang Decotion(XJDH)on Lipopolysaccharide(LPS)-induced fever in rats.One hundred and twenty rats were randomly allotted into four groups:Control group,LPS group,Aspirin group and XJDH group.There were 30 rats in each group.LPS group,Aspirin group and XJDH group were reproduced by intraperitoneal injection of LPS 100μg.kg-1,then Aspirin group and XJDH group were drenched with Aspirin(0.04g.mL-1,10mL.kg-1 in drug delivery according to body weight)and XJDH(1.6g.mL-1,10μg.kg-1 in drug delivery according to body weight) respectively;Control group and LPS group were drenched with saline.The basal body temperature was measured before LPS was injected and then 8h later,2h after administration,6Hypothalamus samples were collected in each group at the point of 2,3,5and 8h.IL-1βand PGE2 were measured.The results showed that,compared with LPS group,the temperature in XJDH group were significantly improved;Compared with the control group,IL-1βof LPS group was significantly increased(P0.05)at 2hand 3h,PGE2 of LPS group was significantly increased(P0.05)at 2h;Compared with LPS group,XJDH significantly lowered the levels of IL-1β and PGE2(P0.05).The above results suggest that XJDH significantly inhibited LPS-induced fever in Rats.The mechanism of initial antipyretic may be related to the inhibition of IL-1β in Hypothalamus,and reduce the release of PGE2。
【Fund】: 北京市教委科技面上项目(KM201210020008);; 国家自然科学基金(31101850);; 北京市自然科学基金(6132007);; 科研基地-科技创新平台(PXM2012_014207_000013);; 北京农学院2012年度科研质量提高经费资助(PXM2012_014207_000010);; 北京市教委人才强教深化计划-学术创新团队(PHR201007142);; 北京市属高等学校人才强教计划资助项目(PHR201107134)
【CateGory Index】: S853.7
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