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《Chinese Journal of Animal and Veterinary Sciences》 2013-08
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Molecular Diagnosis and Allele Frequency of the Insertion of 15 Nucleotides in Bovine Factor XI Gene

LI Qiang1,ZHANG Yi1*,WANG Ya-chun1,WU Meng2,XU Xian-zhou2, ZHANG Zhi-jun2,SUN Dong-xiao1,YU Ying1,ZHANG Sheng-li1,ZHANG Yuan1(1.Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture, College of Animal Science &Technology,China Agricultural University,Beijing 100193,China; 2.Snowdragon Beef Co.,Ltd.,Dalian 116031,China)  
Factor XI deficiency caused by an insertion of 15 nucleotides in bovine Factor XI gene is a newly identified genetic defect that results in blood coagulation disorder in Japanese Black cattle.To analyze the distribution frequency of the defect gene in cattle population in China in current study,two new methods were developed(capillary electrophoresis-based genotyping and allele-specific amplification) to sensitively discriminate the alleles.Using these methods,452 individuals were genotyped from 14 cattle breeds or populations,including Japanese Black bulls,a breeding herd and a commercial herd with Japanese Black cattle blood,four Chinese local breeds(Luxi,Yanbian,Menggu,Fuzhou),two composite breeds(Chinese Holstein,Xinjiang Brown),and six foreign breeds(Simmental,Charolais,Limousine,Angus,Montbeliard,Norwegian Red).The results showed that the defect allele frequency was 0.182,0.389 and 0.242 in Japanese Black bulls,the breeding herd and commercial herd with Japanese Black cattle blood,respectively,1 carrier was found in Yanbian cattle,and the mutation was not found in other cattle populations.The result suggest that the mutation only exist in cattle populations in Northeast Asia and Northeast region in China.The mutation will be detected and eliminated during crossing,improving and breeding the local cattle by Japanese Black cattle and then the unfavorable allele frequency will be reduced.
【Fund】: 国家科技支撑计划(2011BAD28B02;2012BAD12B01);; 现代农业产业技术体系建设项目(CARS-37;CARS-38);; 教育部“分子育种技术”创新团队基金(IRT1191);; 中央高校基本科研业务费专项基金
【CateGory Index】: S823
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