Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Animal and Veterinary Sciences》 2013-08
Add to Favorite Get Latest Update

Molecular Diagnosis and Allele Frequency of the Insertion of 15 Nucleotides in Bovine Factor XI Gene

LI Qiang1,ZHANG Yi1*,WANG Ya-chun1,WU Meng2,XU Xian-zhou2, ZHANG Zhi-jun2,SUN Dong-xiao1,YU Ying1,ZHANG Sheng-li1,ZHANG Yuan1(1.Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture, College of Animal Science &Technology,China Agricultural University,Beijing 100193,China; 2.Snowdragon Beef Co.,Ltd.,Dalian 116031,China)  
Factor XI deficiency caused by an insertion of 15 nucleotides in bovine Factor XI gene is a newly identified genetic defect that results in blood coagulation disorder in Japanese Black cattle.To analyze the distribution frequency of the defect gene in cattle population in China in current study,two new methods were developed(capillary electrophoresis-based genotyping and allele-specific amplification) to sensitively discriminate the alleles.Using these methods,452 individuals were genotyped from 14 cattle breeds or populations,including Japanese Black bulls,a breeding herd and a commercial herd with Japanese Black cattle blood,four Chinese local breeds(Luxi,Yanbian,Menggu,Fuzhou),two composite breeds(Chinese Holstein,Xinjiang Brown),and six foreign breeds(Simmental,Charolais,Limousine,Angus,Montbeliard,Norwegian Red).The results showed that the defect allele frequency was 0.182,0.389 and 0.242 in Japanese Black bulls,the breeding herd and commercial herd with Japanese Black cattle blood,respectively,1 carrier was found in Yanbian cattle,and the mutation was not found in other cattle populations.The result suggest that the mutation only exist in cattle populations in Northeast Asia and Northeast region in China.The mutation will be detected and eliminated during crossing,improving and breeding the local cattle by Japanese Black cattle and then the unfavorable allele frequency will be reduced.
【Fund】: 国家科技支撑计划(2011BAD28B02;2012BAD12B01);; 现代农业产业技术体系建设项目(CARS-37;CARS-38);; 教育部“分子育种技术”创新团队基金(IRT1191);; 中央高校基本科研业务费专项基金
【CateGory Index】: S823
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 ZHU Yong-xiong(Hainan Station for the Extension of Animal Technique,Haikou 570203,China);Measurement of the Body Conformation for Hainan Black Crossbred Cattle and Hybridization Analysis[J];Hubei Agricultural Sciences;2012-09
2 Han Futian, Xue Jun and Lin Bingcheng *(Dalian Institute of Chemical Physics , the Chinese Academy of Sciences, Dalian, 116012);DNA Polymorphism Analysis by Capillary Electrophoresis[J];CHINESE JOURNAL OF CHROMATOGRAPHY;1997-04
3 XIN Xiao-ting1,2,WANG Rong1,2,JIA Zheng-ping1,XIE Hua1,GAO Lan2,LIU Yong2,LIU Yuan-yuan2,MA Jun1,WANG Juan1 (1.Department of Pharmacy,Lanzhou General Hospital of the People′s Liberation Army,Lanzhou 730050,China;2.Life Science College,Lanzhou University,Lanzhou 730000,China);Gene Mutation Detection of Lung Cancer by Capillary Electrophoresis[J];Journal of Instrumental Analysis;2009-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Jin Yan; Lin Bingcheng (Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023);Separation of Deoxyribonucleic Acid by Capillary Electrophoresis in Polymer Solutions[J];CHINESE JOURNAL OF ANALYTIEAL CHEMISTRY;2000-01
2 XIE Xi-Hui 1,2,WANG Rong 1,2,JIA Zheng-Ping1,2,XIE Hua1 ZHAMG Ai-Mei3,XU Juan1,WANG Xiao-Li1,WANG Xian-Hua11(State Base for Drug Clinical Trails,Lanzhou General Hospital of Chinese People′s Liberation Army,Lanzhou 730050)2(Pharmacy College,Lanzhou University,Lanzhou 730000) 3(Life Science College,Northwest Normal University,Lanzhou 730070);Determination of Mutation of C-myc Oncogene in Gastric Cancer by Capillary Electrophoresis[J];Chinese Journal of Analytical Chemistry;2011-11
3 ZHANG Ai-Mei1,2,SUN Kun1,WANG Rong3,XIE Hua3,XIE Xi-Hui 3,SHI You-Qin3 1(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070) 2(College of Life Science,Northwest Normal University,Lanzhou 730070) 3(Department of Pharmacy,Lanzhou General Hospital of the Chinese People′s Liberty Army,Lanzhou 730050);Detection Method of Deoxyribonucleic Acid-Protein Interaction Products and Its Application in Gastric Cancer Tissue[J];Chinese Journal of Analytical Chemistry;2011-12
4 LU Shaohong 1 LONG Xiangli 2 (1 Shenyang Institute of Aeronautical E ngineering,Liaoning Shenyang 110034;2 Huadong Sicience and Technologe university.Shanghai 200237);Applications of capillary electrophoresis in the field of biology[J];Journal of Shenyang Institute of Aeronautcal Engineering;2002-02
5 YangZhaoqing;Chu Jiayou;Lin Keqin(Institute of Medical Biology ,CAMS,Kunming 650107);Application of ASPCR and silver Staining in Molecular Diagnosis of β-Thalassemia[J];ACADEMIC JOURNAL OF KUNMING MEDICAL COLLEGE;1996-01
6 LIU Yong1,2,WANG Rong1,2,GAO Lan1,JIA Zheng-ping1,2,XIN Xiao-ting1,XIE Hua2,MA Jun2(1.Life Science College,Lanzhou University,Lanzhou 730000,China;2.Base of Clinic Pharmacology,Lanzhou General Hospital,Lanzhou Military Command,Lanzhou 730050,China);Separation of DNA Fragment by Capillary Electrophoresis Using Gold Nanoparticle-containing Sieving Medium[J];Journal of Instrumental Analysis;2009-08
7 XIE Xi-hui1,2,WANG Rong1,2,XIE Hua2,JIA Zheng-ping1,2, ZHANG Ai-mei3,MENG Xian-dong2,MA Jun2(1.Pharmacy College,Lanzhou University,Lanzhou 730000,China;2.State Base for Drug Clinical Trails, Lanzhou General Hospital of PLA,Lanzhou 730050,China;3.Life Science College, Northwest Normal University,Lanzhou 730070,China);Methodology Research on Loss of Heterozygosity of APC Gene Detection Exon 11 of Gastric Cancer by Capillary Electrophoresis[J];Journal of Instrumental Analysis;2011-05
8 YU Bing1,2,LIU Peng1,CONG Hai-lin1,2,ZHANG Li-xin1,ZHANG Jiang-tao1 (1.College of Chemical and Environmental Engineering,Qingdao University,Qingdao 266071,China;2.Laboratory for New Fiber Materials and Modern Textile,Growing Base for State Key Laboratory,Qingdao University,Qingdao 266071,China);Research Progress of Capillary Electrophoresis Coatings[J];Journal of Instrumental Analysis;2011-08
9 XIE Yan1,FAN Xue-hua1,WU Xiao-ping1,ZHANG Yi1,LIU Lin3,GONG Wei-jia2, CHEN Shao-hu2,SUN Dong-xiao1,ZHANG Sheng-li1,ZHANG Yuan1(1.College of Animal Science and Technology,China Agricultural University,Beijing 100193, China;2.Dairy Data Processing Center,Dairy Association of China,Beijing 100085,China; 3.Beijing Dairy Cattle Center,Beijing 100085,China);Detection of CN and DUMPS Carriers in Holstein Bulls and Pedigree Analysis[J];Chinese Journal of Animal and Veterinary Sciences;2012-03
10 LIU Xiaolei,HU Chengjin (Liaoning Medical University,Liaoning,Jinzhou 121001,China);Progress in detection methods on molecular targets of lung cancer and clinical applications[J];Journal of Molecular Diagnostics and Therapy;2011-05
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 MA Nai-xiang (Department of Biological Sciences of Hainan Vocational and Technical College,Haikou,Hainan 570216,China);Discussion on Germplasm Conservation and Utilization of Hainan Yellow Cattle[J];Journal Yellow Cattle Science;2005-06
2 Chen Qiao-Yun1,2, Wang Rong1, Jia Zheng-Ping1, Wang Ye-Qiu3, Liu Yuan-Yuan2,Xie Hua1, Ma Jun11(Department of Pharmacy, Lanzhou General Hospital of People′s Liberty Army of China, Lanzhou 730050)2(Life Sciences College, Lanzhou University, Lanzhou 730000)3(Jiamusi College Heilongjiang University of Traditional Chinese Medicine, Jiamusi 154007)4(Life Sciences College, Northwest Normal University, Lanzhou 730070);Fast Detection of P53 Gene Mutation of Gastric Cancer by Restriction Fragment Length Polymorphism With Capillary Electrophoresis[J];Chinese Journal of Analytical Chemistry;2007-09
3 Jia Hai1,2,3 , Wang Rong1, Jia Zheng-Ping1, Cheng Qiao-Yun1,2, Xie Hua1, Ma Jun1, Ao Yan11(Department of Pharmacy, Lanzhou General Hospital of People′s Liberation Army of China, Lanzhou 730050)2(The People Hospital of Gansu Province,Lanzhou 730000)3(School of Pharmacy, Lanzhou University, Lanzhou 730000);Study of Single Strand Deoxyribonucleic Acid Separation Theory by Capillary Electrophoresis and MFOLD Software[J];Chinese Journal of Analytical Chemistry;2007-09
4 闫威,贾静涛,姜先华,吕世惠;A New Staining Method of Cardiac Conducting System[J];Journal of Forersic Medicine;1995-02
5 PanJun (North east Agricultural University 150030);Origination and Characteristics of Japanese Cattle Breeds[J];HEILONGJINAG JOURNAL OF ANIMAL REPRODUCTION;1994-01
6 XIE Min-jie,ZHUZhou,YUYong-fei,WANG Wei,XUYun-lan (Department of Neurology,Tongji Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan430030,China);Measurements of PC12Cells Apoptosis with Capillary Electrophoresis[J];Journal of Instrumental Analysis;2005-03
7 WANG Rong1,JIA Zheng-ping1,JIA Hai1,2,CHEN Qiao-yun1,3,XIE Hua1,MA Jun1,LI Wen-bin1(1.Base of Clinical Pharmacology,Lanzhou General Hospital of People's Liberation Army,Lanzhou 730050,China;2.Department of Pharamcary,The People Hospital of Gansu Province,Lanzhou 730000,China;3.Jiamusi College,Heilongjiang University of Traditional Chinese Medicine,Jiamusi 154007,China);Development of Tumor Marker Analysis by Capillary Electrophoresis Method[J];Journal of Instrumental Analysis;2008-11
8 WANG Hong-Mei, LI Jian-Bin, HOU Ming-Hai, WANG Chang-Fa, LI Qiu-Ling, ZHONG Ji-Feng Dairy Cattle Center of Shandong Academy of Agricultural Sciences, Ji’nan 250100, China;The development and application of method for detecting bovine complex vertebral malformation[J];Hereditas;2008-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved