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《Journal of Animal Science and Veterinary Medicine》 2014-02
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Effects and Efficacy Assessment of Su-Kang Detoxification Oral Liquid on Astragalus Strictus Poisoned Rabbits

HAO Bao-cheng;YANG Xian-peng;WANG Xue-hong;LIU Jian-zhi;WANG Bao-hai;GUO Wen-zhu;GUO Zhi-ting;LIU Yu;SHANG Ruo-feng;HU Yong-hao;LIANG Jian-ping;Key Laboratory of New Animal Drug Project,Gansu Province/Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agricultural/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of ,CAAS;Institute of Animal Husbandry and Veterinary,Tibet Academy of Agricultural and Animal Husbandry Sciences;College of Veterinary Medicine,Gansu Agricultural University;  
Astragalus was fed artificially to 2-month-old experimental rabbits to cause poisoning.Three experimental groups were set including control group,intoxication group,detoxification treatment group,each group with four experimental rabbits,to establish poisoning and detoxification pathological model.On 28-d(poisoning death),45-d(poisoning death) and 49-d(detoxification and control groups were sacrificed),pathological changes of rabbits were investigated and the effect of oral treatment of Su-Kang detoxification were evaluated.The results demonstrated on 18-d detoxification treatment group the rabbits occurred poisoning symptom,on 28-d dead rabbits were found in intoxication group,on 29-d detoxification treatment group was cured by Su-Kang oral liquid,none dead rabbit was found,which showed that the model was established successfully.Pathology slices observations showed that the organs of the intoxication group rabbits showed serious pathological changes such as congestion,inflammation,necrosis and so on,the detoxification treatment group showed mild gore,mild cell degeneration.Therefore,the Su-Kang detoxification oral solution can effectively improve theα-mannose glycosides enzyme activity and detoxifying group test rabbits exhibited mild pathological changes,it confirms that the Su-Kang detoxification oral solution has good detoxifying effect.
【Fund】: 国家高新技术研究发展计划(863计划)课题编号:2011AA10A214;; 中央级公益性科研院所基本科研业务费专项资金(项目编号:1610322012001);; 西藏横向委托项目:预防动物疯草中毒解毒新制剂的研制(2011-2013)
【CateGory Index】: S859.87
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