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《Medical Journal of National Defending Forces in Southwest China》 2006-03
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Molecular epidemiological investigation of relationship between HV natural infection and HFRS in pigs

YANG Zhan-qing, YU Shou-yi, NIE Dong, CHEN Qing, LI Jian-jun, LI Zhi-feng, LIU Yun-xi, ZHANG Jing-lan, YU Xiao-min, SU Jing-jing, LI Jing, CHEN Shao-ling, ZHANG Yun, TAO Kai-hua, ZHANG Li-ping Department of Epidemiology, South Medical University, Guangzhou, 510515 Center for Disease Prevention and Control of Jinan Military Command, Jinan, 250014 Center for Disease Control and Prevention of Nanjing Military Command, Nanjing, 210000; Department of Pharmacy, General Hospital of Jinan Military Command, Jinan, 250014.  
To realize the epidemiological importance role of pig in hemorrhagic fever with renal syndrome (HFRS) foci and to explore the relationship between the Hantaan virus(HV) natural infection and the incidence of HFRS in pigs. Methods: HV antigens and antibodies in the samples from various tissues and organs of pigs were detected by IFA, RPHA, immuno-enzyme dye, RT-PCR. Results: HV antigens and antibodies were detected in heart, lung, liver, spleen, kidney, blood, urine, feces, and saliva, and HV were isolated from various samples with positive antigen. It was revealed that pig was sensitive to HV, and HV distributed in various organs of pig. Re-infections were successful by pigs' tissues, blood, and egesta with positive antigen. HV antigens were also detected in spleen, lung, kidney, and brain of young pig, which indicated that HV seemed to enter directly into central nerve system, and participate in damnification of cerebral tissues. Conclusion: Pigs have the preconditions acting as the spreading hosts of HFRS
【CateGory Index】: S858.28
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