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《JOURNAL OF SOUTHWEST AGRICULTURAL UNIVERSITY》 2000-03
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STUDIES ON IMMUNOMODULATION FUNCTION OF SWEET POTATO GLYCOPROTEIN

KAN Jian-quan, YAN Lei, CHEN Zong-dao, HE Zhi-fei, WANG Guang-ci (College of Food Science, Southwest Agricultural University, Chongqing 400716, China)  
A study of immunomodulation function of Beijing No.2 sweet potato glycoprotein (SPG) purified with DEAE52 and Sephadex G 100 column chromatography showed that lymphocyte transformation induced by PHA from human peripheral blood was promoted as the conce tration of purified SPG was above 50 μg/ml, especially when it was 100 or 150 μg/ml, the stimulation index being 6.5 or 4.5 (P0.05),respectively. At a dose of 80 mg/kg. d, by means of peritoneal injection, phagocytosis of peritoneal macrophages of mice was promoted and the phagocytic index and phagocytic percent were higher than those in any other group (P0.05). The determination of spleen index and thymus index in mice gave similar results. Light- and electron-microscopic examination showed that the spleen lymph nodules were enlarged and increased with SPG dose, and the number of mitochondria in thymus T cells increased, too. Such results indicated that purified SPG can markedly enhance immunomodulation function.
【CateGory Index】: TQ936.223
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