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《Journal of Ningxia Medical College》 2008-02
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Antivirus Effects of Dureping Injection on Cellular Factor of Th1/Th2 in Mice

ZHANG Yan-li1,FAN Xin-sheng2,GU Li-gang2,LI Peng-tao2 (1.Dept.of Etiology and Immunology of Ningxia Med.Coll.,Yinchuan,750004;2.Dept.of Etiology and Immunology of Beijing University of Chinese Medicine,Beijing 100029)  
Objective To explore the antivirus effect of Dureping Injection in mice.Methods The murine pneumonia model was establish by influenza virus strain A/FM/1/47(H1N1).The bioactivity of interleuking-4(IL-4) and interferonγ(IFN-γ) in the murine lung was detected by ELISA.The murine Death Rate was observed.Results Dureping Injection decreased the bioactivity of IL-4 and increased the bioactivity of IFN-γ.It showed 0.33 g/(kg·d) and 0.17 g/(kg·d)of Dureping Injection had significantly protective effect to death of the mouse with virus pneumonia.Conclusion Dureping Injection has an obvious effect against influenza virus FM1 strain by correcting the Th1/Th2 cell shift,regulating the bioactivities of Th1 cytokines and the bioactivies of Th2 cytokines,which reach a new balance between Th1 cell and Th2 cell.
【Fund】: 国家自然科学资助基金(30772872);; 国家“863”计划创新药物与中药现代化重大专项(2005AA2Z3Foo)
【CateGory Index】: R285.5
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