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《Journal of Ningxia Medical University》 2012-06
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Influence of Small Dose of Dexamethasone on AQP4 in Rats with Brain Trauma

YANG Zhen-xing1,LI Zong-zheng2(1.Ningxia Medical University,Yinchuan 750004;2.Department of Neurosurgery, the General Hospital of Ningxia Medical University,Yinchuan 750004)  
Objective To establish animal model of fluid percussion injury and to explore the relationship between dexamethasone and AQP4 in rats.Methods The brain injury model was made by the method of Feeney's free-fall.The rats were randomly divided into three experimental groups: sham group,TBI group and experimental group.According to the time points of sacrifice such as 6h,12h,24h,3d and 5d after injury,the TBI group and experimental group was also randomly divided into five experimental sub-groups and the content of brain water and the mRNA and the protein level of the AQP4 were investigate.Results The content of the brain water in TBI group increased in 6h(79.49±0.45)%,reached its peak at 24h(81.61±0.68)%,it remained at a high level in 3d(80.88 ± 0.93)%,and then began to reduce in 5d(80.08 ± 0.85)%.The expression of AQP4 in TBI group increased in 6h(0.18±0.01),reached its peak at 24h(0.18±0.01),it remained at a high level in 3d to(0.20±0.01),and continued higher at 5d(0.19±0.01).The mRNA and the protein level of AQP4 and the content of brain water showed the consistent trend,however,significant difference between two indices was found at the same time point.Conclusion Low-dose dexamethasone may alleviate encephaledema by down regulating the mRNA and protein level of AQP4.
【CateGory Index】: R651.15
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