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《Journal of Ningxia Medical University》 2017-07
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Effects of Ultrasound-guided Supraclavicular Branchial Plexus Block on T-lymphocyte and NK Cells in Patients undergoing Upper Surgery

CHEN Yaru;LI Zhenzhou;MENG Jinhai;Department of Anesthesiology,the General Hospital of Ningxia Medical University;  
Objective To explore the effects of ultrasound-guided supraclavicular branchial plexus block on T-lymphocyte and NK cells in patients undergoing upper surgery. Methods 80 patients scheduled for receiving upper surgery were equally divided into two groups,supraclavicular branchial plexus block group(group supraclavicular branchial plexus block)and total intravenous anesthesia group(Group total intravenous anesthesia). In group supraclavicular branchial plexus block,ultrasound-guided infraclavicular brachial plexus block was performed. Continuous infraclavicular brachial plexus block for postoperative pain control. In group total intravenous anesthesia,total intravenous anesthesia was performed. Postoperative patient-controlled analgesia with continuous intravenous sufentanil infusion. Patients' venous blood samples for T-lymphocyte subset(CD3~+,CD4~+,CD8~+)and NK cells were collected before the surgery(T_0)and at 0 h(T_1),1st day(T_2),3rd day(T_3)after the surgery. Results Compared with those on T_0,The levels of CD3~+,CD4~+,CD4~+/CD8~+and NK cells on T_1,T_2 and T_3were significantly lower in total intravenous anesthesia group(P0.05). The levels of CD3~+,CD4~+,CD4~+/CD8~+and NK cells on T_1 and T_2were significantly lower in supraclavicular branchial plexus block group(P0.05). The levels of CD3~+,CD4~+,CD4~+/CD8~+and NK cells were significantly higher in group supraclavicular branchial plexus block than in group total intravenous anesthesia on T_2 and T_3(P all 0.05). Conclusion The recovery of cellular immune function undergoing upper extremity surgery under supraclavicular brachial plexus block is earlier than that of total intravenous anesthesia.
【Fund】: 宁夏医科大学科学研究基金(XM2015072)
【CateGory Index】: R614
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