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Effect of Chaihu-Guizhi Decoction on Healing Quality of Experimental Gastric Ulcer in Rats

MEI Wuxuan 1,DENG Lanqiong 2,CUI Shigao 2 1 Department of Gastroenterotogy,Frist Affiliated Hospital,Xianning Medical College,Xianning 437100 2 The Affiliated Hospital of Hubei Traditional Chinese Medicine College,Wuhan 430061  
Objective To investigate the effect of Chaihu Guizhi decoction (CHGZ) on quality of ulcer healing (QOUH) in rats.Methods The rat model of chronic gastric ulcer was prepared with acetic acid and randomly divided into A,B and C group,which were given normal saline,CHGZ and cimetidine respectively.Then,the regenerated mucosa of healed gastric ulcer was observed quantitatively by using histochemical mucus stain and hematoxylin eosin stain,the contents of nitric oxide (NO) of gastric mucosa was measured by using biochemical methods.Results The thickness of regenerative mucosa in scar of group B and C were significantly thicker than that of group A (P0.01),the width of defective muscularis mucosa in ulcer scar in B and C was significantly narrower than that of A (P0.01),furthermore,the contents of NO and the mucus index in B and C were significantly higher than that in A (P0.01;0.05).The mucus index and contents of NO of group B were significantly higher than that of C (P0.01;P0.05).Conclusion CHGZ can improve QOUH—it is one of possible mechanisms for preventing the relaps of peptic ulcer by usimg CHGZ in clinic.
【Fund】: 湖北省教委科技基金!资助项目 (95A0 34 )
【CateGory Index】: R285
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Chinese Journal Full-text Database 3 Hits
1 YANG Xuesong; LI Yinong; YE Simao; DONG Xiuyun(Department of Gastroenterology, The Third Hospital,Beijing Medical University 100083);EXPERIMENTAL STUDY OF CORRELATION OF GASTRIC ULCER HEALING QUALITY WITH RISISTANCE TO REINJURY BY PREDNISONE IN RATS[J];Journal of Beijing Medical University;1996-06
2 Yan HM, Li YK;Progress in studies on nitric oxide in chronic gastritis[J];WORLD CHINESE JOURNAL OF DIGESTOLOGY;1999-04
3 Yan Shun-qin; Feng Liang-yuan;Su Ying-hao; et al (Anhui College of TCM, Hefei 230038);Protective Effect of "Wei Tong Ling" on Gastric Mucosa and Influence on Quality of Gastric Ulcer Healing[J];CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1995-10
Chinese Journal Full-text Database 10 Hits
1 HE Zhen-ming Sanatorium Clinic of Huangshan Military Branch Region,Anhui 245000;Analysis of 32 clinical cases of digestive ulcer relaspe[J];Journal of Anhui Health Vocational & Technical College;2004-03
2 Ye Heng(Department of Internal Medicine of Nanan City Hospital,Nanan,Fujian,362300);Effect of Welikang on gastric ulcer induced by acetic acid in rats[J];Journal of North Pharmacy;2012-06
3 LIU Jian-ping HU Dong-ju(Hospital of Traditional Chinese Medicine in Hebei Province,Shijiazhuang 050011);Study of Effect of Weixikang Apozema on Growth Factor of Acetic Acid Gastric Ulcer Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
4 LIU Fen,YANG Qiang(College of Medicine,Hubei!University for Nationalities,Enshi 445000,China);The Therapeutic Effects and Mechanism of Resistance to Reinjury by Prednisone of JW Decoction on Experimental Gastric Ulcer in Rats[J];Journal of Hubei Institute for Nationalities(Medical Edition);2008-02
5 LIANG Zhi-gen QUAN Hua-bin. Department of Internal Medicine,Zhongshan People's Hospital,Zhongshan(528403),China;Long-term efficacy of lansoprazole combined with hydrotalcite in treatment of peptic ulcer[J];International Journal of Digestive Disease;2006-06
6 HE Cheng long,CHEN Yi zhao,WANG Yi shan,etc(Guide:LIN He xi)(1.The Traditional Chinese Medicine Hospital of Quanzhou,362000;2.Fujian New Drug Base Study Fuzhou 350001);The Development and Pharmaceutical Experiment of WeiLing KeLi(WLKL)[J];Strait Pharmaceutical Journal;2002-05
7 ZHANG Xian-hua1,MAO Jing-hua2(Xiamen collage Hospital,Xiamen 361005,China;2.Fujian Xianzhi biological Tech.Co.Ltd.Fuzhou,350002.China);To study effect of weiling chongji on quality of ulcer healing in gastric ulcerated rats[J];Strait Pharmaceutical Journal;2007-02
8 ZHANG Zhi-yong1,SUN Gong-kai2,YANG Shi-zhong2 (Affiliated Hospital of Hainan Medical University,Haikou 570102,China);Influence of appetite promotion decoction on the mucosal healing and EGF expression in gastric ulcer model mice[J];Journal of Hainan Medical University;2010-06
9 WEI Wei,LIN Shou-ning,HUANG Gui-hua,TENG Jiu-xiang(TCM University of Hunan,Changsha,Hunan 410007,China);Effects of Anwei decoction on EGF of gastric ulcer in rats[J];Journal of Traditional Chinese Medicine University of Hunan;2008-06
10 YU Qiu-ying1,LI Xin-xin2,HAO Wei1,CHEN Kui-min1 (1.Department of Pharmacology Shenyang Medical College,Shenyang,Liaoning,110034 P.R.China;2.Forensic Identification Center of Shenyang Medical College,Shenyang,Liaoning,110034 P.R.China);Effect of Butylamine roxatidine acetate on the apoptosis of ulcer edge mucosal cells in the rats with gastric ulcer[J];West China Journal of Pharmaceutical Sciences;2011-03
Chinese Journal Full-text Database 10 Hits
1 Shi Meiya,Zha Ansheng (The First Affiliated Hospital,Anhui College of TCM,Hefei 230031,China);60 CASES OF DUODENAL ULCER TREATED BY QILIAN DECOCTION[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
2 Wei Song,Sun Bigang,Shen Ying,et al(General Hospital of Chinese PLA Guangzhou Command Area,Guangzhou,510010);THE CHANGE OF GMBF IN PATIENTS OF STOMACHACHE WITH SPLEEN DEFICIENCY SYNDROME[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1998-02
3 ZHANG Qing you 1, DU Jun bao 1, SHI Lin 1,ZHANG Chun yu 1, YAN Hui 1, TANG Chao shu 2 (1.Department of Pediatrics, 2.Institute of Cardiovascular Research,Peking University First Hospital, Beijing 100034, China);Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension[J];Journal of Peking University(Health Sciences);2004-01
4 GENG Bin1, DU Jun-bao2, TANG Chao-shu 1△(1.Institute of Cardiovascular Research, 2.Department of Pediatrics,Peking University First Hospital, Beijing 100034,China);Application of sensitive sulphur electrode assay to measure and analyze cystathionine-γ-lyase/hydrogen sulfide pathway of cardiovascular tissues, cells and plasma in rats[J];Journal of Peking University(Health Sciences);2005-05
5 Department of Nutrition and Food Hygiene Lin Xiaoming,et al;EFFECT OF TREMELLA, PORIA AND GYNOSTEMMA ON MURINE IMMUNOLOGICAL AND SCAVENGING FREE RADICALS FUNCTION[J];Journal of Beijing Medical University;1995-06
6 LI Shuxin;KU Baoshan;LIN Zhibin(Department of Pharmacology,Beijing Medical University 100083);EFFECT OF MURAMYL DIPEPTIDE ON SKEEP AND ITS RELATIONSHIP TO TNF[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1996-04
7 YANG Xuesong; LI Yinong; YE Simao; DONG Xiuyun(Department of Gastroenterology, The Third Hospital,Beijing Medical University 100083);EXPERIMENTAL STUDY OF CORRELATION OF GASTRIC ULCER HEALING QUALITY WITH RISISTANCE TO REINJURY BY PREDNISONE IN RATS[J];Journal of Beijing Medical University;1996-06
8 KU Bao Shan (Department of Pharmacology, Beijing Medical University, Beijing 100083);Pharmacological study of slow wave sleep[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1999-03
9 Zhang Lei; Zhang Guanghua; Liu Wentao;Wang Shuqin; Wang Yi; Wei Hong; Yun Siyuan(Chengdn University of Traditional Chinese Medicine Chengdu 610075);Developing Law of Epigastric Pain Syndromes──A Report of 7315 Cases[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1995-04
10 MEI Zhe-chuan 1, LUO Yong-ping 2, HE Lu 1,et al. (1.Department of Digestive Diseases,the Second Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400010,China;2.Department of Digestive Diseases, the Second People′s Hospital of Yibin,Yibin 644000,China);Epidemiological survey of peptic ulcer after the eradicative treatment of helicobacter pylori: endoscopic analysis of 30993 cases[J];Chongqing Medical Journal;2005-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 TANG Mei-wen~1,LUO Wei-sheng~1,LI Gui-xian~2,HE Zhen-hua~2,DENG Chang~2,HUANG Yong-hua~1(1.Guangxi Traditional Chinese Medical Unviersity, Nanning, 530001;2. The First Affiliated Hospital, Guangxi TCM University, Nanning, 530023);Experimental Research on Effects of Qifang WeiTong Capsule on Gastric Ulcer[J];Journal of Guangxi Traditional Chinese Medical University;2005-03
2 Yang Li,Nian Xiuling Yancheng People′s Hospital,Luohe Henan China 462300;Clinical Research of Yudan Shengui Capsule in the Treatment of Early Diabetic Nephropathy with Microalbuminuria[J];China Journal of Chinese Medicine;2013-05
3 AN Jun,WEI Feng-ling,CUI Gang(Pharmacy Department,China-Japan Friendship Hospital,Beijing 100029,China);Experimental study on pharmacodynamics of Tonglin granule[J];Practical Pharmacy and Clinical Remedies;2013-06
4 XU Mu-ge,WEI Kai-feng(Corresponding Author)(Nanjing University of Chinese Medicine,Jiangsu Nanjing 210023,China);Analysis on Mechanisms of Activating Blood Circulation and Compatible Regularity of Cinnamon Twig[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2013-08
5 LI Chang-an(Hospital of traditional chinese medicine of Mingguang,Mingguang 239400,Anhui,China);Chaihu Guizhi Decoction treatment of 40 Patients with Functional Dyspepsia[J];Journal of Practical Traditional Chinese Internal Medicine;2011-06
6 MEI Wu-xuan1,CENG Chang-chun2,YU Na1(1.Department of Medicine,Xianning Medical College,Xianning 437100,China;2.Department of Photomedicine,South China Normal University,Guangzhou 510631,China);Effects of Jianpi Huoxue Recipe on the Activities of H~+,K~+-ATPase and Gastrin Receptor in Gastric Parietal Cells of Gastric Ulcer in Rats[J];Lishizhen Medicine and Materia Medica Research;2009-11
7 Gao Sheng1,Zhou Jing2(1.Tianjin Nankai Hospital,Tianjin 300100;.2 The First Affiliated Hospital of Tianjin University of Traditional Chinese Medical,Tianjin 300193);Analysis of 100 prescriptions of coronary heart disease caused congestive heart failure[J];Tianjin Pharmacy;2012-04
8 YU Can1a,LI Xucheng1b,WANG Ling2(1a.Department of Respiratory Medicine,Wuhan Chinese Medicine Hospital,Wuhan 430014,China; 2b.Department of Emergency Medicine,Wuhan Chinese Medicine Hospital,Wuhan 430014,China; 2.Department of Fundamental Nursing,College of Nursing,Hubei University of Chinese Medicine,Wuhan 430065,China);Review on Clinical Experience for Treating Cervical Spondylosis of LI Xucheng[J];Journal of Practical Traditional Chinese Internal Medicine;2013-01
9 Zhao-Hong Shi Jie-Mei Zhang Department of Gastroenterology,Wuhan First Municipal Hospital,Wuhan 430022,Hubei Province,China Hui-Fang Zhou Hai-Fang Yang Zhou Chen Yun-Xia Feng Hubei College of Traditional Chinese Medicine,Wuhart 430061,Hubei Province,China;Effect of Cuyu granule on the quality of ulcer healing in tats with gastric ulcer induced by acetic acid[J];World Chinese Journal of Digestology;2007-15
10 LIU Xi-rong1,LIN Shou-ning2.(1.Guangxi Traditional Chinese Medical College,Nanning 530001,China;2.Department of Gastroenterology,the Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical College,Nanning 530011,China);Development of Experimental Researches about Traditional Chinese Medicine in Improving Quality of Gastric Ulcer Healing[J];Medical Recapitulate;2010-02
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Yu Jing-rei Sun You-fang(Department of pathology, Railway central Hospital, Wuhan. 430064);THE DIAGNOSTIC SIGNIFICANCE OF NUCLEOLAR ORGANIZER RECAIONS IN CANCER AND PRECANCEROUS LESIONS OF THE STOMACH[J];Chinese Journal of Cancer;1993-01
2 Gao Zhan 1, Zhu Yunlong 1, Mei Qi 1, Chen Jiankang 1, Huang Weiquan 2, Wu Changgui 3 1Department of Physiology, 2Department of Histology and Embryology, Fourth Military Medical University, Xi'an 710033 3Department of Respiration, Xiji;Study of immunohistochemical localization of NOS in gastrointestinal tract of rat[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1997-04
3 Yang Chunmin Zhou Lu Zhang Hang Hao Wei(Department of Physiology,Institute of Basic Medical Sciences,CAMS and School of Basic Medicine PUMC,Beijing 100005);Regulatory Role of Nitric Oxide in Migrating Motor Complex of Stomach and Duodenum in Dogs[J];BASIC MEDICAL SCIENCES AND CLINICS;1997-06
4 Wang Xiaonong.Li Aihong.Xu Hongyue The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011;The Clinical Significance of Serum NO_2~- /NO_3~- Levels in Different Morbid Conditions[J];Tianjing Medical Journal;1996-10
5 Fan Jianzhen① Lu Fanggen② Wushaoping② Gao Jieshen①①Central Laboratory ②Department of GastroenterologyThe second Affiliated Hospital of Hunan Medical University;ANALYSIS OF NITRIC OXIDE LEVEL IN THE GASTRIC JUICE OF PATIENTS WITH DUODENAL ULCER AND CHRONIC GASTRITIS[J];CHINESE JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY;1997-02
6 Yan Changdon; Chen Min; Gu Luo; et al(Department of Physiology, Xuzhou Medical College,Xuzhou, Jangsu 221002, China);EFFECT OF ENDOGENOUS NITRIC OXIDE ON GASTRIC MUCOSAL BLOOD FLOW AND GASTRIC MUCOSAL LESION IN RATS[J];ACTA ACADEMIAE MEDICINAE XUZHOU;1995-02
7 Hao zhiming,Zhang Shangzhi,Cheng Zhangzhu,et al. First University Hospital,West China UniverSity of Medical Sciences.;THE PBOTECTIVE EFFECT AND MECHANISM OF AMOXICILLIN AGAINST RESERPINE-INDUCED GASTRIC ULCERATION IN RATS[J];CHINESE JOURNAL OF DIGESTION;1995-05
9 Chen Yongxiang et al (Flrst Affiliated Hospital, Guiyang College Traditional Chinese Medicine, Guiyang 550001);The Effects in the Prophylactive Treatment Yiguan Jian on Four Experimental Gastric Ulcer[J];Pharmacology and Clinics of Chinese Materia Medica;1990-04
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