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《JOURNAL OF XIANNING MEDICAL COLLEGE》 2000-03
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Effect of Chaihu-Guizhi Decoction on Healing Quality of Experimental Gastric Ulcer in Rats

MEI Wuxuan 1,DENG Lanqiong 2,CUI Shigao 2 1 Department of Gastroenterotogy,Frist Affiliated Hospital,Xianning Medical College,Xianning 437100 2 The Affiliated Hospital of Hubei Traditional Chinese Medicine College,Wuhan 430061  
Objective To investigate the effect of Chaihu Guizhi decoction (CHGZ) on quality of ulcer healing (QOUH) in rats.Methods The rat model of chronic gastric ulcer was prepared with acetic acid and randomly divided into A,B and C group,which were given normal saline,CHGZ and cimetidine respectively.Then,the regenerated mucosa of healed gastric ulcer was observed quantitatively by using histochemical mucus stain and hematoxylin eosin stain,the contents of nitric oxide (NO) of gastric mucosa was measured by using biochemical methods.Results The thickness of regenerative mucosa in scar of group B and C were significantly thicker than that of group A (P0.01),the width of defective muscularis mucosa in ulcer scar in B and C was significantly narrower than that of A (P0.01),furthermore,the contents of NO and the mucus index in B and C were significantly higher than that in A (P0.01;0.05).The mucus index and contents of NO of group B were significantly higher than that of C (P0.01;P0.05).Conclusion CHGZ can improve QOUH—it is one of possible mechanisms for preventing the relaps of peptic ulcer by usimg CHGZ in clinic.
【Fund】: 湖北省教委科技基金!资助项目 (95A0 34 )
【CateGory Index】: R285
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