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《Journal of Xianning College(Medical Sciences)》 2003-02
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An Acute Toxicity Testing of the Allium Sativum L Polysaccharide and It's Effect on the Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) in Injured Mice Serum or Liver

ZHENG Min ,PAN Shi-bin JIANG You-ding ,et al (Department of Pharmacology, Xianning College, Xianning Hubei 437100, China )  
Objective To study the effects of the allium sativum L polysaccharide A,B and C on the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in injured mice serum or Liver and to detect the Acute Toxicity. Methods The Allium sativum L polysaccharide A,B and C were extract from garlic root-stem. The acute toxicity were observed by medial lethal dose(LD50)and acute maximal tolerance dose toxicity testing. The experimental liver injury model was reestablished by 500 mL/L carbon tetrachloride solution(0. 1ml/10g,ig). ALT and AST in serum or liver were assayed by biochemical method. Results LD50 of the Allium sativum L polysaccharide A,B and C on mice for oral administration could not be detected. The acute maximal tolerance dose toxicity testing found that the Allium sativum L polysaccharide A,B and C (5g/kg·d ig×14) didn't show obvious toxicity on mice. Allium sativum L polysaccharide A,B and C(0.6g/kg. d ig×10) could obviously reduce the activities of ALT and AST in serum and increase activities of ALT and AST in liver in carbon tetrachloride (CCL4)-treated mice(P0. 01), and the action of three components were gradually increased in order. For the effects on the ALT and AST, component C were most powerful and stronger than allitridi, component B were less powerful and similar with allitridi, while component A were inferior to allitridi. Conclusion The allium sativum L polysaccharide A, B and C were all the new effective liver protection ingredient in garlic with less toxicity,the allium sativum L polysaccharide C show more powerful liver protecting activity.
【CateGory Index】: R285
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