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《Journal of Xianning College(Medical Sciences)》 2004-06
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Effects of Tamoxifen on Structure of Testes in Mice

SHE Tong-hui,ZHAO Hong-gang,GAN Ya-ping,et al (Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430030,China)  
Objective To observe the effects of Tamoxifen(TAM ) on the structure of testes of mice. Methods TAM was administra ted to mice at different doses(0.02mg·kg -1· d -1、0.2mg·kg -1·d -1、2mg·kg -1·d -1)by gavage once a day for successive 20 days. The mice were sacrificed on the 35th day afte r the first gavage. The change of bod-weight, the weight of testes and the inde x of testes were examined pre-and post-experiment and the structures of testis were observed. Results The change of body-weight and the ind ex of testes in high TAM group were significantly different with those in negati ve control group(p0.05).The structures of testes in high TAM group were also obviously injured. Conclusion High dose of TAM has toxicity to the tissues of testes in mice.
【CateGory Index】: R965.2
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