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《Southwest China Journal of Agricultural Sciences》 2014-02
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Pathological Observation and Swainsonine Determination on Spontaneous Locoweeds Intoxication of Goats

WANG Shan-shan;WANG Bao-hai;YANG Xiao-wen;CI Renduoji;ZHAO Bao-yu;LU Hao;CHEN Ji-ping;College of Veterinary Medicine,Northwest A&F University;Academy of Agriculture and Animal Husbandry in Tibet Autonomous Region;  
Two goats were intoxicated by Astrugalus variabilis spontaneously in Alxa,Inner Mogolia. The tissues of the goats were collected to study the histology process,histology lesions of cerebellum,heart,liver by HE stain,the ultrastructure changes were studied using transmission electron microscope,swainsonine content of tissues were determined by Gas Chromatograph. Results showed that the most prominent lesion was cytoplasmic vacuolation in neurons,Purkinje cells,hepatocytes,renal tubular epithelial cells,etc. Ultrastructurally,there were many vacuoles surrounded by single layer membranes in the cytoplasm,and there were inflammatory cells in the blood vessels. Mitochondria cristae broke and degenerated. Swainsonine could be detected in liver,kidney and brain,and muscle tissues and blood from poisoning goat,but there was no swainsonine determined in lung and gastrointestinal tissues.
【Fund】: 公益性行业专项“草原主要毒害草发生规律与防控技术研究”(201203062)
【CateGory Index】: S858.27
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