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《Southwest China Journal of Agricultural Sciences》 2019-08
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Effect of Konjac Glucomannan on LO2 Cell Line with Cadmium Poisoning

LI Ying-xin;YUAN Xi;WANG Zhen-yu;HUANG Lei;QIN Wen-jun;ZHAO Qin;Research Center of Swine Disease,College of Veterinary Medicine,Sichuan Agricultural University;  
[Objective]The effect of konjac glucomannan(KGM)on the cytotoxicity of L02 cell line induced by cadmium was studied.[Method]The optimal concentration and aseptic treatment way of KGM solution were determined by MTT method.Set control group,only cadmium treated group,cadmium treated for 3 hours then treated with KGM group,KGM treated 3 hours then treated with cadmium group,the cells in all groups were cultured to the setting times,then used MTT method to detective the viability of L02 cells,and the content of ALT,AST,GSH-Px and MDA were detected by appropriate reagent kits,the morphology of L02 cells were also observed under light microscope.[Result]The best concentration and sterilization treatment for KGM solution was 0. 2 mg/mL after 30 min treatment at 121 ℃ And there was obvious dose-effect relationship between the viability of L02 cell line and the concentration of CdCl_2 solution.Compared with control group,the cadmium treated for 3 hours then treated with KGM group and KGM treated 3 hours then treated with cadmium group both showed higher cell viability,and the contents of ALT,AST,MDA were significantly different.[Conclusion]Therefore,KGM can protect L02 cells after cadmium exposure to some extent.
【Fund】: 四川农业大学大学生科研兴趣计划(ky2016074)
【CateGory Index】: R285.5
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