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Mechanical ventilation strategies in neonates with chronic lung disease

NONG Shao-han, ZHONG Jin, JIANG Qiu-ping, XIE Yan-ming, HE Shao-ru, ZHANG Yu-he, ZHONG Min-quan, SUN Yun-xia, ZHUANG Jian. Department of Neonatal Medicine, Guangdong Provincial People's Hospital, Guangzhou 510080, China  
Objective To study the mechanical ventilation strategies in neonates with chronic lung disease (CLD) before and after the onset of the disease. Methods Twenty-four neonates with CLD were mechanically ventilated with lung-protective ventilation strategies before and after the diagnosis was made, and their clinical data were retrospectively analyzed. Results Among these twenty-four neonates, there were two death (8.3%), one improved (4.2%), and the other twenty-one babies recovered completely and were discharged home (87.5%). Nine babies were ventilated intermittently after CLD diagnosed, seven of them survived and were discharged home. Steroid treatment was started on eight neonates with CLD and three of them were discontinued because of side effects. Conclusions Lung-protective ventilation strategies are effective and important methods for prevention and treatment of neonatal CLD. Nasal intermittent mechanical ventilation or nasal continuous positive airway pressure ventilation is an effective method waning infants from ventilator.
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