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《Prevention and Treatment of Cardio-Cerebral-Vascular Disease》 2008-03
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The Effect of Puerarin on Left Ventricular Hypertrophy in 2K1C Renal Hypertension Rats.

JIN Ge,YANG Peng-lin,GONG Yong-sheng,et al.Department of Cardiovascular Internal Medicine,the Second Affiliated Hospital,Wenzhou Medical College,Zhejiang 325027,China  
Objective To examine the effect of puerarin on left ventricular hypertrophy in the two-kidney,one-clip(2K1C) rats.Methods Thirty male Sprague-Dawley rats were randomly divided into normal control group(N),model group(M) and puerarin group(P).The mean of carotid arterial pressure(mCAP),mean of left ventricular end diastolic pressure(LVEDP),the maximum rate of change in left ventricular pressure(LV±dp/dtmax),and the weight ratio of left ventricular mass(left ventricle plus septum)to body weight(LVM/BW) were measured in all rats.Morphological change of myocardium was investigated under transmission electron microscope.Results ① Compared with N group,the mCAP,LVEDP and LVM/BW in M group rats were higher to 36.58%(P0.05),333.8%(P0.01) and 20.24%(P0.01),respectively,but LV+dp/dtmax was lower 85.35%(P0.05).However,LV-dp/dtmax was of no significant difference between two groups.② Compared with M group,LVEDP,LVM/BW and LV-dp/dtmax in P group rats were lower 65.24%(P0.05)、13.12%(P0.05) and 96.28%(P0.01),respectively,but LV+dp/dtmax was higher 179.18%(P0.01).However,mCAP was of no significant difference between two groups.③ Under transmission electron microscope,loosen and dissolved myofilament were observed at left ventricle in model rats.Otherwise,intercalated disc was widen;the area under tunica muscularis was lightly swollen;and karyopyknosis was also observed easily.But nor in C and P groups.Conclusions The treatment of puerarin showed that it could effectively reverse the left ventricular hypertrophy in 2K1C renal hypertension rats.
【Fund】: 温州市科技局资助课题(Y2003A104)
【CateGory Index】: R285.5
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