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《Advances In Cardiovascular Diseases》 2005-02
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Effects of Local Angiotensin Ⅱ and Endothelin-1 on Hypertensively Myocardial Hypertrophy

ZHANG Fang-ning, LI Yu-ming(Cardiovascular Diseases Research Institute of Armed Police Force, Tianjin 300162, China)  
Renin-angiotensin system(RAS)is one of the important neuroendocrine system of body and plays an important role in the regulation of blood pressure and equilibration of body fluid.Recent studies indicate that local angiotensinⅡ(AngⅡ)and endothelin-1(ET-1)are related to hypertensively myocardial hypertrophy.Evidences of the activation of local AngⅡ and ET-1 were detected in animal model of hypertensively myocardial hypertrophy and patients with hypertensively myocardial hypertrophy.After being activated,local AngⅡ and ET-1 can affect the occurrence and characteristics of hypertensively myocardial hypertrophy through multiple mechanisms,thus affect the initiation and perpetuation of hypertensively myocardial hypertrophy.Beneficial effects have been achieved by different measure of intervention for local AngⅡ and ET-1.This review focuses on the issues mentioned above.
【CateGory Index】: R541.3
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