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《Advances In Cardiovascular Diseases》 2005-S1
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β-Adrenoceptor Agonist and Cardiomyocyte Apoptosis

HE Zhong-mei, LIU Hui-rong (Department of Physiology,Shanxi Medical University, Taiyuan 030001, China)  
β-adrenoceptor is one of major receptors participating in the regulation of cardiac function.Stimulation of the receptor results in the alteration of cardiac function to fit to the diverse changes of circumstance.But under long-term stimulation of the receptor can induce myocardial injury including apoptosis.This article reviews the signaling pathway of myocardial apoptosis induced by β-adrenoceptor agonist including the protein kinase A (PKA),Ca 2+ / calcineurinⅡ,mitogen-activated protein kinases(MAPKs) and so on.
【Fund】: 山西省自然科学基金(20021103);; 山西医科大学基础医学院科研方向建设基金(20040708)
【CateGory Index】: R541
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